Results 231 to 240 of about 22,964,900 (284)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Editorial: Prognostic value of inflammatory and thrombotic biomarkers in acute coronary syndrome. [PDF]

Front Cardiovasc Med
Menichelli D, Gatto L, Biccirè FG.
europepmc   +1 more source

Impacts of stress hyperglycemia ratio on functional outcomes of ischemic stroke patients treated with intravenous thrombolysis: a population-based study. [PDF]

Front Neurol
Li D, Deng L, Han Y, Lai J, Qin L, Dong X, Ren L, Xu G.   +7 more
europepmc   +1 more source

Exploratory analyses of clinical trials - what can they tell us and what are the potential pitfalls? [PDF]

Nat Commun
europepmc   +1 more source

Social impact bonds: opportunities for funding health promotion and disease prevention. [PDF]

BMC Public Health
Plankó S, Hulse E, Rutten-van Mölken M, Goossens L, Wordsworth S, Koleva-Kolarova R, Tsiachristas A, Wright S, Zemplényiné Bartha J, Nagy B, Babarczy B.   +10 more
europepmc   +1 more source

Ethical considerations in the clinical application of prediction tools for severe mental disorders: perspectives from child and adolescent psychiatrists. [PDF]

Glob Bioeth
Neiders I, Kalēja J, Mileiko I, Poļaka I, Mežinska S.   +4 more
europepmc   +1 more source

Blood N1-methyladenosine (m¹A) RNA modification and outcome after cardiac arrest. [PDF]

Crit Care
Stopa V, Sopic M, Bernardin F, Legrave NM, Zhang L, Stammet P, Devaux Y.   +6 more
europepmc   +1 more source