Results 181 to 190 of about 61,248 (207)

Urinary lithogenic factors in urolithiasis patients with kidney disease and correlation with renal function. [PDF]

Front Med (Lausanne)
Dong Q, Xu H, Xu P, Liu J.
europepmc   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Diabetic kidney disease: emerging mechanistic and nutritional perspectives from the Mediterranean diet-mitochondria axis. A narrative review. [PDF]

J Nutr Health Aging
Mercurio G, Giacco A, Scopigno N, Vigliotti M, Petito G, Moreno M, Cioffi F, Silvestri E.   +7 more
europepmc   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

Uric acid-associated mechanisms of coronary artery calcification in diabetic kidney disease: evidence, hypotheses, and translational perspectives. [PDF]

Front Cardiovasc Med
Li S, Liu Y.
europepmc   +1 more source

A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation‐Induced Lung Injury by Targeting Ferroptosis

Advanced Science, EarlyView.
An inhalable, nanoengineered herbal therapy achieves protection against acute radiation‐induced lung injury via self‐assembled nanomicelle‐mediated pulmonary targeting and a previously unrecognized dual mechanism that attenuates oxidative stress while inhibiting ferroptosis in alveolar epithelial cells.
Li Quan, Junyang Chen, Xingmin Chen, Zengyi Fang, Yuanzhen Mi, Pingjin Zou, Shunlian Fu, Huakang Li, Ke Xu, Bing Lin, Jinyi Lang, Meihua Chen   +11 more
wiley   +1 more source

Hyperinsulinemic hypoglycemia in renal glucosuria in the presence of a novel sodium-glucose cotransporter 2 variant. [PDF]

JCEM Case Rep
Cadogan S, Madden A, O'Dwyer O, Kavanagh K, O'Byrne JJ, Byrne MM.   +5 more
europepmc   +1 more source

Low fruit and vegetable intake in children: a dietary stressor raising renal ammonium and adrenal cortisol secretion. [PDF]

Pflugers Arch
Remer T, Hua Y, Esche J, Shi L, Hartmann MF, Wudy SA.   +5 more
europepmc   +1 more source

A framework of biomarkers for renal aging: a consensus statement by the Aging Biomarker Consortium. [PDF]

Life Med
Aging Biomarker Consortium, Zhang X, Chen A, Lv L, Ma L, Zheng Y, Ma B, Zhong Z, Jing Y, Qiu A, Shao Y, Zhang W, Cen J, Zhou L, Chen W, Zhang C, Li J, Chen J, Yang B, Liu Y, Qu J, Yi F, Zhao J, Liu BC, Ruan XZ, Lu L, Zheng F, Liu GH, Pei G, Nie J, Guan Y.   +30 more
europepmc   +1 more source

Adhesion GPCRs in Kidney: New Insights into Development, Physiology and Disease. [PDF]

Cells
Myrzatayeva A, Singh AK, Engel FB.
europepmc   +1 more source