Results 131 to 140 of about 372,494 (306)

Presence of Potentially Toxic Elements in Historical Mining Areas in the North-Center of Mexico and Possible Bioremediation Strategies

Toxics
This paper provides an overview of the impacts of mining-related environmental liabilities on humans, soils, sediments, surface water and groundwater across various mining districts in Zacatecas, Mexico.
Victor Manuel Escot-Espinoza, Susana Rodríguez-Márquez, Jorge Briseño-Bugarín, Maria Argelia López-Luna, Juan Armando Flores de la Torre   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Assessment of the concentration and health risk of potentially toxic elements in agricultural soils of the Bastam Plain (Semnan Province) [PDF]

علوم زمین خوارزمی
In order to investigate the concentration and the health risk of potentially toxic elements in the agricultural soils of the Bastam Plain, 14 surface soil samples (0-20 cm) were collected. Physico-chemical characteristics and total concentration of major
Javid Khaghani, Giti Forghani
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Sustainable groundwater management through water quality index and geochemical insights in Valsad India

Scientific Reports
Groundwater quality assessment is crucial for sustainable water resource management and public health protection. This study evaluated the Water Quality Index (WQI) of groundwater in the southern part of Gujarat focusing on the Valsad District ...
Keval H Jodhani, Nitesh Gupta, Sanidhya Dadia , Harsh Patel, Dhruvesh Patel, Punyawi Jamjareegulgarn , Sudhir Kumar Singh, Upaka Rathnayake   +7 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effects of composting manures and other organic wastes on soil processes and pest and disease interactions [PDF]

, 2003
Introduction Composts and manures are of major importance in providing fertility in organic farming systems, since synthetic fertilisers are prohibited. It is understood that composts have radically different nutrient release characteristics to those of
Harrier, L., Litterick, Audrey, Wallace, P., Watson, C. A., Wood, M.   +4 more
core  

Assessment of potentially toxic element contents in chickens and poultry feeds from Bangladesh markets: Implications for human health risk

Toxicology Reports
Chicken (Gallus domesticus) is a significant source of animal protein for the people of Bangladesh. However, anthropogenic activity may contaminate chicken meat with potentially toxic elements (PTEs) despite the nutritional benefits. Current work aims to
Shamim Al Mamun, Mohammad A. Islam, Shamshad B. Quraishi, Mohammad M. Hosen, Brett H. Robinson, Ismail M.M. Rahman   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source