Results 101 to 110 of about 2,388,447 (384)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Working to Reduce Poverty: A National Subsidized Employment Proposal

RSF: The Russell Sage Foundation Journal of the Social Sciences, 2018
Subsidized employment programs that increase labor supply and demand are a proven, underutilized strategy for reducing poverty in the short and long term.
Indivar Dutta-Gupta, Kali Grant, Julie Kerksick, Dan Bloom, Ajay Chaudry   +4 more
doaj   +1 more source

Poverty and Psychology

SSRN Electronic Journal, 2015
This paper presents a study on the association between dimensions of poverty (income, subjective socioeconomic status, deprivation, and socioeconomic status in childhood) and individual psychological characteristics. In this study, our goal was to determine: 1) the differences in individual psychological characteristics between poor and non-poor people;
Seger M. Breugelmans, Maria Efremova, Olga V. Poluektova   +2 more
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Recognition and poverty [PDF]

Eidos, 2015
Despite the increasing popularity of Axel Honneth’s recognition theory across philosophy and the social sciences, there is almost no philosophical literature on the relation between recognition and poverty from this perspective. In this paper I am concerned with three questions related to such a reflection.
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Socioeconomic inequalities in avoidable mortality in Italy: results from a nationwide longitudinal cohort

BMC Public Health
Background Disparities in avoidable mortality have never been evaluated in Italy at the national level. The present study aimed to assess the association between socioeconomic status and avoidable mortality.
Alessio Petrelli, Martina Ventura, Anteo Di Napoli, Marilena Pappagallo, Silvia Simeoni, Luisa Frova   +5 more
doaj   +1 more source

Use of a mobile application for Ebola contact tracing and monitoring in northern Sierra Leone: a proof-of-concept study

BMC Infectious Diseases, 2019
Background The 2014–2016 Ebola epidemic in West Africa was the largest Ebola epidemic to date. Contact tracing was a core surveillance activity. Challenges with paper-based contact tracing systems include incomplete identification of contacts, delays in ...
Lisa O. Danquah, Nadia Hasham, Matthew MacFarlane, Fatu E. Conteh, Fatoma Momoh, Andrew A. Tedesco, Amara Jambai, David A. Ross, Helen A. Weiss   +8 more
doaj   +1 more source

Poverty Matters: It's Now 50/50, Chicago Region Poverty Growth is a Suburban Story [PDF]

, 2013
Nationwide, the number of people in poverty in the suburbs has now surpassed the number of people in poverty in central cities. Cities have long been thought to be home to the most and worst poverty. However, in the past several decades, the suburbs have
Amy Terpstra, Jennifer Clary, Nicole Kreisberg   +2 more
core  

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source