Results 121 to 130 of about 1,989,813 (313)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Using the 99DOTS (directly observed treatment, short course) application for improved adherence to tuberculosis treatment in Namibia: A mixed-methods study

open access: yesSouth African Medical Journal
Background. In Namibia, community-based directly observed tuberculosis (TB) treatment (C-DOT) has been effective for individuals living in settled villages, but it is problematic for mobile indigenous people who survive through hunting and gathering
M Claassens   +3 more
doaj   +1 more source

Poverty in Buffalo: Causes, Impacts, Solutions [PDF]

open access: yes, 2018
This policy report examines the scope of poverty and inequality in Buffalo-Niagara, the causes of poverty, and its impacts across health, homelessness, education, and more.
Bergsten, Alyssa   +6 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Factors associated with cervical cancer screening: results from cross-sectional surveys in Kenya and Malawi

open access: yesBMC Public Health
Background Cervical cancer screening is an essential public health intervention, and critical to meeting the Global Strategy for Cervical Cancer Elimination goals – yet most women in low- and middle-income countries are never screened. There is a need to
Corrina Moucheraud   +9 more
doaj   +1 more source

Growth, inequality, and poverty in Spain, 1850-2000: evidence and speculation. [PDF]

open access: yes, 2006
Was the Civil War (1936-39) originated by staggering inequality and extreme poverty? How did Franco's dictatorship (1939-75) affect inequality and poverty?
Departamento De   +3 more
core   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Measuring Poverty in South Africa [PDF]

open access: yes, 1999
This paper sets out the methodological issues for the measurement of poverty before presenting a poverty profile of South Africa. It tests the sensitivity of the poverty profile to choices around the metric used to measure well-being, the equivalence ...
Woolard, Ingrid, Leibbrandt, Murray
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Half in Ten: Why Taking Disability into Account is Essential to Reducing Income Poverty and Expanding Economic Inclusion [PDF]

open access: yes, 2009
Disability is both a fundamental cause and consequence of income poverty. The income-poverty rate for persons with disabilities is between two to three times the rate for persons without disabilities.
Shawn Fremstad
core  

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