Results 121 to 130 of about 816,124 (307)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Factors associated with cervical cancer screening: results from cross-sectional surveys in Kenya and Malawi

BMC Public Health
Background Cervical cancer screening is an essential public health intervention, and critical to meeting the Global Strategy for Cervical Cancer Elimination goals – yet most women in low- and middle-income countries are never screened. There is a need to
Corrina Moucheraud, Symon Chibaka, Ginger Golub, Pericles Kalande, Amos Makwaya, Eric Ochieng, Vitalis Ogutu, Khumbo Phiri, Sam Phiri, Risa M. Hoffman   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The role of early childhood care and education – an anti-poverty perspective

, 2008
The remit of this paper is to explore the role of early childhood care and education from an anti-poverty perspective through considering the child outcome ‘child poverty’ and the potential benefits of early childhood services.
Hayes, Nóirín Dr.
core  

Multidimensional Poverty Index 2010 : two page briefing [PDF]

, 2010
The Multidimensional Poverty Index (MPI) is a new international measure of poverty. Covering 104 developing countries, the MPI complements income poverty measures by reflecting the acute deprivations that people face at the same time.
(OPHI), Oxford Poverty & Human Development Initiative
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Moving Out of Poverty : Volume 2. Success from the Bottom Up

, 2009
The global moving out of poverty study is unique in several respects. It is one of the few large-scale comparative research efforts to focus on mobility out of poverty rather than on poverty alone.
Narayan, Deepa, Kapoor, Soumya, Pritchett, Lant   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Multidimensional Poverty Index 2011 : two page briefing [PDF]

, 2011
The Multidimensional Poverty Index (MPI) is an international measure of poverty. Covering 109 developing countries, the MPI complements income poverty and Millennium Development Goals (MDGs) measures by reflecting the acute deprivations that people face ...
(OPHI), Oxford Poverty & Human Development Initiative
core   +1 more source

Contemporary Labour Market Policy and Poverty in South Africa [PDF]

, 1999
This paper outlines the recent labour market reforms in South Africa and discusses their likely impact on poverty and the working poor. Using an innovative framework developed elsewhere in the literature, the paper shows how labour market processes and ...
Maziya, Muzi
core   +1 more source