Results 121 to 130 of about 11,568,905 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Chagas disease in an area of recent occupation in Cochabamba, Bolivia

open access: yesRevista de Saúde Pública
INTRODUCTION: A descriptive, entomological and seroepidemiological study on Chagas disease was conducted in a place of recent occupation on the outskirts of Cochabamba, Bolivia: Avaroa/Primer de Mayo (population:3,000), where the socio-economic level is ...
Hugo Albarracin-Veizaga   +5 more
doaj  

Addressing poverty and inequality in the mountains of Pakistan

open access: yesDiscover Global Society
This paper examines poverty and inequality in Pakistan's mountains, using nationally representative data. Our analysis reveals that, despite a slight decline in poverty rates, overall rates remain alarmingly high, with significant variations across ...
Golam Rasul, Apsara Karki Nepal
doaj   +1 more source

Government Intervention Strategy in Poverty Reduction

open access: yesJurnal Bina Praja
Poverty remains a significant challenge in Indonesia, with a national rate of around 9.36% in 2023 and 16 provinces exceeding this poverty level. This study aims to analyze poverty patterns across districts and cities by using K-Means Clustering and ...
Aln Pujo Priambodo   +1 more
doaj   +1 more source

Rural Tourism as a Mechanism for Poverty Alleviation in Kwa-Zulu-Natal Province of South Africa: Case of Bergville. [PDF]

open access: yesAfrican Journal of Hospitality, Tourism and Leisure, 2018
The case of rural tourism and community development has been made in general terms with less focus on poverty alleviation and more emphasis on economic modernisation.
Dr Burney Mthembu   +1 more
doaj  

Poverty in the Brazilian Amazon: An Assessment of Poverty Focused on the State of Para

open access: yes, 2004
The states in the Brazilian Amazon have made progress in reducing poverty and improving social indicators in the last decade. Despite this progress, the poverty rate in the Amazon is among the highest in Brazil.
Verner, Dorte
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

open access: yesFEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo   +7 more
wiley   +1 more source

Area Poverty and Adverse Birth Outcomes

open access: yesObstetrics & Gynecology
OBJECTIVE: To evaluate the association between area poverty and adverse birth outcomes in the diverse birthing population of a large health system. METHODS: This was a retrospective cohort study using electronic health record and hospital administrative data for pregnant people at ...
Madden, Nigel   +4 more
openaire   +2 more sources

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