Results 51 to 60 of about 154,276 (266)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The Survey of Poverty Status in the Rural and Urban Areas in Fars Province [PDF]
Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2009 Fars province, with the population almost equal to the 6.5 percent of the total country population and noticeable geographic-wide and remarkable facilities and suitable economic-social capabilities, always has been encounter to defects and shortages ...
Khosrow Piraee, Mohammad Reza Shahsavar
doaj
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Oral health literacy and oral health behaviors of disadvantaged women residing in the slum area of Zahedan, Iran: A cross-sectional study [PDF]
Journal of Oral Health and Oral EpidemiologyBackground: Disadvantaged subjects are considered a high-risk group due to limited access, insufficient awareness regarding the importance of oral health, and lack of preventive behavior.
Azam Dahmardeh +3 more
doaj
Acta Scientiarum: Biological Sciences, 2012 This study reviews the debate concerning socioeconomic impacts of established protected areas on local populations. On one side, there are those who defend the idea that protected areas may assist in poverty reduction by generating alternative sources ...
Rodrigo de Jesus Silva +1 more
doaj +1 more source
Estimating the Impacts of Bolivia’s Protected Areas on Poverty [PDF]
World Development, 2012 Summary Bolivia has experienced a rapid proliferation of protected areas over the past several decades. Using rich biophysical and socioeconomic data, we estimate the impacts of Bolivia’s protected areas on poverty between 1992 and 2001. We find no evidence that the establishment of protected areas exacerbated poverty.
Canavire-Bacarreza, Gustavo J +1 more
openaire +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source