Results 71 to 80 of about 11,568,905 (297)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

When work disappears: new implications for race and urban poverty in the global economy

open access: yesCelebrating 40 Years of Ethnic and Racial Studies, 2019
This paper discusses the impact of growing joblessness and dwindling work opportunities on inner-city areas in America. The lack of low-skilled manual work in the inner city is linked to poverty, crime, family dissolution and the social life of ...
William Julius Wilson
semanticscholar   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Food Security and Climate Change in Dry Areas: Abstracts

open access: yes, 2022
The dry areas of the developing world occupy some 3 billion hectares and are home to one-third of the global population. About 16% of the population lives in chronic poverty, particularly in marginalized rainfed areas.
(ICARDA), International Center for Agricultural Research in the Dry Areas
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Oral health literacy and oral health behaviors of disadvantaged women residing in the slum area of Zahedan, Iran: A cross-sectional study [PDF]

open access: yesJournal of Oral Health and Oral Epidemiology
Background: Disadvantaged subjects are considered a high-risk group due to limited access, insufficient awareness regarding the importance of oral health, and lack of preventive behavior.
Azam Dahmardeh   +3 more
doaj  

The Survey of Poverty Status in the Rural and Urban Areas in Fars Province [PDF]

open access: yesFaslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2009
Fars province, with the population almost equal to the 6.5 percent of the total country population and noticeable geographic-wide and remarkable facilities and suitable economic-social capabilities, always has been encounter to defects and shortages ...
Khosrow Piraee, Mohammad Reza Shahsavar
doaj  

POVERTY IN A RURAL AREA: THE ROLE OF THE SOCIAL WORKER

open access: yesSocial Work/Maatskaplike Werk, 2014
There are many ways of looking at poverty. When poverty is measured in absolute terms, itrefers to the financial means necessary for people to survive from day to day. The most basicmeasures of poverty in South Africa are the Minimum Living Level (MLL) and the HouseholdSubsistence Level (HSL).
Strydom, Corinne, Tlhojane, M.E.
openaire   +4 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Conservation assumptions and development in Brazilian Cerrado - doi: 10.4025/actascibiolsci.v35i1.12480

open access: yesActa Scientiarum: Biological Sciences, 2012
This study reviews the debate concerning socioeconomic impacts of established protected areas on local populations. On one side, there are those who defend the idea that protected areas may assist in poverty reduction by generating alternative sources ...
Rodrigo de Jesus Silva   +1 more
doaj   +1 more source

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