Results 71 to 80 of about 5,300,961 (303)

Targeting Research for Enhanced Impact on Poverty in Marginal Areas: The Representative Case of the Dry Areas of Syria [PDF]

open access: yes
Agricultural research in marginal dry areas can contribute to reducing poverty through the development of technological, institutional and policy options for poor farmers by addressing diversified opportunities and development pathways.
La Rovere, Roberto, Aw-Hassan, Aden
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A Study on the status of poverty in urban areas of Kerman province in comparison with the whole country [PDF]

open access: yesFaslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2014
The first step to fight against poverty and inequalities reduction in line with development policy, is correct understanding and awareness of poverty situation. Due to this thread, this paper studies the relative poverty in urban areas of Kerman province
Pooneh Eftekharian, Mostafa Salimifar
doaj  

Factor Capitalization,Industry Development and Targeted Poverty Alleviation——Based on the Investigation of Danzhai County,Guizhou Province

open access: yesContemporary Social Sciences, 2018
At present, targeted poverty alleviation is a major development strategy in China. Based on the investigation of Danzhai County in Guizhou Province, this paper argues that industry development is the fundamental measure through which to implement the ...
Zhang Haipeng
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Violência e desigualdade social: mortalidade por homicídios e condições de vida em Salvador, Brasil

open access: yesRevista de Saúde Pública
OBJETIVO: A relação entre pobreza e violência tem sido questionada por alguns autores. Nesse sentido, foi realizado estudo com o objetivo de analisar os diferenciais intra-urbanos de mortalidade por homicídio segundo as condições de vida. MÉTODOS: Estudo
Adriana C Macedo   +3 more
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Intervenção comunitária e redução da vulnerabilidade de mulheres às DST/ Aids em São Paulo, SP

open access: yesRevista de Saúde Pública
OBJETIVOS: Com o aumento do número de casos notificados de Aids em mulheres, as intervenções comunitárias, que são fundamentais nesse contexto, são poucas e raramente avaliadas.
Regina Figueiredo   +1 more
doaj  

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