Results 71 to 80 of about 159,626 (263)
Intervenção comunitária e redução da vulnerabilidade de mulheres às DST/ Aids em São Paulo, SP
Revista de Saúde PúblicaOBJETIVOS: Com o aumento do número de casos notificados de Aids em mulheres, as intervenções comunitárias, que são fundamentais nesse contexto, são poucas e raramente avaliadas.
Regina Figueiredo +1 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Spatial spillover effect of multi-dimensional poverty in Malawi
Humanities & Social Sciences CommunicationsHigh and persistent levels of multidimensional poverty pose a significant challenge in Malawi. Finding effective methods to eradicate poverty in all its forms remains a key policy concern.
Edson Ntodwa, Gowokani Chijere Chirwa
doaj +1 more source
BMC Public Health, 2017 Background This study is the first to examine associations between several area-based socioeconomic factors and human papillomavirus (HPV) vaccine uptake among boys in the United States (U.S.). Methods Data from the 2012-2013 National Immunization Survey-
Kevin A. Henry +4 more
doaj +1 more source
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, EarlyView.
Jonathan Cunningham
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
An Assessment of the Level, Trend, and Distribution of Multidimensional Poverty in Iran
برنامهریزی و بودجه, 2020 An accurate, and time-based poverty measurement is crucial in future policymaking as well as assessing the impact of welfare policies implemented on poverty.
Yadollah Dadgar +2 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source