Results 91 to 100 of about 159,626 (263)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chagas disease in an area of recent occupation in Cochabamba, Bolivia

Revista de Saúde Pública
INTRODUCTION: A descriptive, entomological and seroepidemiological study on Chagas disease was conducted in a place of recent occupation on the outskirts of Cochabamba, Bolivia: Avaroa/Primer de Mayo (population:3,000), where the socio-economic level is ...
Hugo Albarracin-Veizaga, Maria Esther de Carvalho, Elvira M M do Nascimento, Vera Lúcia C C Rodrigues, Cláudio Casanova, José Maria S Barata   +5 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Addressing poverty and inequality in the mountains of Pakistan

Discover Global Society
This paper examines poverty and inequality in Pakistan's mountains, using nationally representative data. Our analysis reveals that, despite a slight decline in poverty rates, overall rates remain alarmingly high, with significant variations across ...
Golam Rasul, Apsara Karki Nepal
doaj   +1 more source

Government Intervention Strategy in Poverty Reduction

Jurnal Bina Praja
Poverty remains a significant challenge in Indonesia, with a national rate of around 9.36% in 2023 and 16 provinces exceeding this poverty level. This study aims to analyze poverty patterns across districts and cities by using K-Means Clustering and ...
Aln Pujo Priambodo, Mohammad Ahlis Djirimu   +1 more
doaj   +1 more source

Rural Tourism as a Mechanism for Poverty Alleviation in Kwa-Zulu-Natal Province of South Africa: Case of Bergville. [PDF]

African Journal of Hospitality, Tourism and Leisure, 2018
The case of rural tourism and community development has been made in general terms with less focus on poverty alleviation and more emphasis on economic modernisation.
Dr Burney Mthembu, Dr. Emmanuel Mutambara   +1 more
doaj  

Area Poverty and Adverse Birth Outcomes

Obstetrics & Gynecology
OBJECTIVE: To evaluate the association between area poverty and adverse birth outcomes in the diverse birthing population of a large health system. METHODS: This was a retrospective cohort study using electronic health record and hospital administrative data for pregnant people at ...
Madden, Nigel, Kanugula, Samanvi, Yee, Lynn M., Rydland, Kelsey, Feinglass, Joe   +4 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Evaluation of alcohol outlet density and its relation with violence

Revista de Saúde Pública
OBJECTIVES: The current study set out to investigate alcohol availability in a densely populated, residential area of suburban São Paulo associated with high levels of social deprivation and violence.
Ronaldo Laranjeira, David Hinkly
doaj