Results 51 to 60 of about 1,255,193 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Lessons from China’s Three-Decade Distributed Photovoltaic Development for Yemen

Journal of Sustainable Development of Energy, Water and Environment Systems
Translating global distributed photovoltaic successes to Yemen’s fragile and conflict-affected context remains a critical challenge. This study develops a strategic roadmap by adapting lessons from China's three-decade market evolution, informed by
Karamy Saeed
doaj   +1 more source

Factors Affecting Professional Power of Independent Audit [PDF]

مطالعات تجربی حسابداری مالی, 2004
A wide range of theories and hypotheses positively or normatively have justified the need for presences of audit process as a monitoring body for reassuring financial information provided to the public. There is a consensus that the audit function should
Yahya Hassas Yeganeh, Ruhollah Rajabi
doaj  

Varying Power Configurations and the Accountability of Independent Regulatory Agencies

International Review of Public Policy, 2020
Independent regulatory agencies (IRAs) have a significant capability to choose how to implement their decisions to be effective, given the mix of managerial autonomy, supervisory powers and political independence that most of these agencies enjoy.
Fulya Apaydin, Jacint Jordana
doaj   +1 more source

A Power Independent Detection Method for Ultra Wide Band (UWB) Impulse Radio Networks [PDF]

2005 IEEE International Conference on Ultra-Wideband, 2006
We propose a novel detection method for noncoherent synchronization (signal acquisition) in multi-access UWB impulse radio (IR) networks. It is designed to solve the IUI (inter-user interference) that occurs in some ad-hoc networks where concurrent transmissions are allowed with heterogeneous power levels.
A. El Fawal, J.-Y. Le Boudec
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Multi-Stage Recommendation System for Electric Vehicle Charging Networks

World Electric Vehicle Journal
As the number of electric vehicles (EV) increases, the demand for recommending the best charging location when using a large-scale charge network to charge is also increasing.
Junjie Cheng, Xiaojin Lin
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source