Results 71 to 80 of about 1,267,055 (264)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Completely Independent Spanning Trees in k-Th Power of Graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2018
Let T1, T2, . . . , Tk be spanning trees of a graph G. For any two vertices u, v of G, if the paths from u to v in these k trees are pairwise openly disjoint, then we say that T1, T2, . . . , Tk are completely independent. Araki showed that the square of
Hong Xia
doaj   +1 more source

Investigating the financial closure of projects within the South African renewable energy independent power producer procurement programme

open access: yesSouth African Journal of Industrial Engineering, 2014
South Africa may have a generation capacity shortage in the near future. The Renewable Energy Independent Power Producer Procurement Programme (REIPPPP) is playing an important role in creating generation capacity to fulfil future demand requirements ...
Lotz, Marco, Brent, Alan Colin
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Signal Processing for Transient Flow Rate Determination: An Analytical Soft Sensor Using Two Pressure Signals

open access: yesSignals
Accurate knowledge of the flow rate is essential for hydraulic systems, enabling the calculation of hydraulic power when combined with pressure measurements. These data are crucial for applications such as predictive maintenance.
Faras Brumand-Poor   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Cascaded adaptive load frequency control for single area and double area power systems considering wind penetration

open access: yesScientific Reports
This study investigates the application of a cascaded adaptive controller for Load Frequency Control (LFC) in single-area and two-area power systems. The controller is a combination between adaptive PI controller and PID controller thus the term cascaded
Ahmed EL-Bassiouny   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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