Results 61 to 70 of about 677,386 (264)

DOUBLE-SOURCE ALTERNATE BACKUP TYPE UNIFIED POWER QUALITY CONDITIONER

open access: yesElectrica, 2009
A double-source alternate backup type unified power quality conditioner (DS-UPQC) is proposed in this paper, which consists of two shunt inverters and two series inverters, the shunt inverters are connected alternately to the series inverters through the
Haibo LIU   +3 more
doaj   +2 more sources

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Effect of Sulfur and Chlorine on Fireside Corrosion Behavior of Inconel 740 H Superalloy

open access: yesHigh Temperature Materials and Processes, 2018
Fireside corrosion behavior of Inconel 740H superalloy was studied at 750 °C in simulated coal ash/flue gas environments by means of XRD, SEM and EDS.
Jin-tao Lu   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

THE RESEARCH ON SPECIAL ELECTRONIC POWER TRANSFORMER

open access: yesElectrica, 2009
In many circumstances, three-phase AC power supply is not always the best choice for utility applications. In fact, there is a rating of three-phase to single-phase, three-phase to dual-phase and three-phase to multiphase transformers being in operation ...
Change CHEN   +3 more
doaj   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Interpretable machine learning analysis on CO2 adsorption and separation capacity of biochar under multi-scenario conditions

open access: yesGreen Energy & Environment
Biochar has been widely recognized as a promising solid CO2 adsorbent with economic and ecological benefits. Industrial CO2 emissions originate from diverse sources, while the pore structure and chemical functional groups of biochar exhibit varying ...
Jialiang Dong   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy