Results 41 to 50 of about 10,934,057 (300)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Bonneville Power Administration, Office of Engineering 10-Year Plan, 1992-2001 : Draft.

, 1992
For over 50 years, the Bonneville Power Administration (BPA) has evolved to supply electric power to more than 170 customer utilities and direct service industries across 14,800 miles of high voltage transmission lines.
Engineering., United States. Bonneville Power Administration. Office of
core   +1 more source

Semantic-based policy engineering for autonomic systems [PDF]

, 2004
This paper presents some important directions in the use of ontology-based semantics in achieving the vision of Autonomic Communications. We examine the requirements of Autonomic Communication with a focus on the demanding needs of ubiquitous computing ...
Carey, Kevin, Lewis, D., Carey, K., Simon Courtenage, Thanassis Tiropanis, Courtenage, Simon, Kevin Carey, Feeney, Kevin, Tiropanis, Thanassis, Tiropanis, T., Lewis, David, Courtenage, S., Kevin Feeney, Feeney, K., David Lewis   +14 more
core   +1 more source

The effect of device geometry on the performance of a wave energy converter

Communications Engineering
Wave energy presents an excellent opportunity to add much-needed diversification to the global renewable energy portfolio. However, a competitive levelised cost of electricity for wave energy conversion devices is yet to be proven.
Emma C. Edwards, Craig Whitlam, John Chapman, Jack Hughes, Bryony Redfearn, Scott Brown, Scott Draper, Alistair G. L. Borthwick, Graham Foster, Dick K.-P. Yue, Martyn Hann, Deborah Greaves   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Vibro-Acoustic Methods in the Condition Assessment of Power Transformers: A Survey

IEEE Access, 2019
It has been over two decades since the publication of pioneer works about the power transformer diagnostics based on monitoring of their acoustic fingerprints. Since then, there has been great progress in this field and the methods used are as complex as
Adnan Secic, Matej Krpan, Igor Kuzle
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Quantum Software Engineering Challenges from Developers\u27 Perspective: Mapping Research Challenges to the Proposed Workflow Model [PDF]

, 2023
Despite the increasing interest in quantum computing, the aspect of development to achieve cost-effective and reliable quantum software applications has been slow.
Mikkonen, Tommi, Stirbu, Vlad, Haghparast, Majid, Nurminen, Jukka K.   +3 more
core   +1 more source