Results 61 to 70 of about 113,392 (312)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A cost modelling system for cloud computing [PDF]

open access: yes, 2014
An advance in technology unlocks new opportunities for organizations to increase their productivity, efficiency and process automation while reducing the cost of doing business as well.
Ellman, Jeremy   +5 more
core   +1 more source

Techno-Economic Analysis of Common Work of Wind and Combined Cycle Gas Turbine Power Plant by Offering Continuous Level of Power to Electricity Market

open access: yesJournal of Sustainable Development of Energy, Water and Environment Systems, 2018
Wind power varies over time and variations occur on all time scales, mainly under the influence of meteorological fluctuations. Understanding these variations and their predictability is of key importance for integration and optimal utilisation of wind ...
Željko Tomšić   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Computing nature: turing centenary perspective

open access: yes, 2013
This book is about nature considered as the totality of physical existence, the universe, and our present day attempts to understand it. If we see the universe as a network of networks of computational processes at many different levels of organization ...
Dodig Crnkovic, Gordana   +7 more
core   +1 more source

Solving differential‐algebraic equations in power system dynamic analysis with quantum computing

open access: yesEnergy Conversion and Economics
Power system dynamics are generally modeled by high dimensional non‐linear differential‐algebraic equations (DAEs) given a large number of components forming the network.
Huynh T. T. Tran   +3 more
doaj   +1 more source

A survey on policies, modelling and security of cyber‐physical systems in smart grids

open access: yesEnergy Conversion and Economics, 2021
A more reliable, efficient, and resilient smart grid depends on the applications of advanced information and communication technologies to support new functions and controls.
Qin Wang, Guangyuan Zhang, Fushuan Wen
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Power quality assessment of different load categories

open access: yes, 2017
In this paper, a fuzzy logic based method is proposed to define and evaluate power quality indices for different categories of electricity consumers. The severity level of each power quality disturbance is first estimated according to the frequency of ...
Jiang, Zhuhan (R10087)   +1 more
core   +1 more source

A systematic decision-making framework for tackling quantum software engineering challenges

open access: yes, 2023
Quantum computing systems harness the power of quantum mechanics to execute computationally demanding tasks more effectively than their classical counterparts.
Rafi, Saima   +2 more
core   +1 more source

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