Results 61 to 70 of about 114,070 (312)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Small scale software engineering [PDF]

, 1981
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.In computing, the Software Crisis has arisen because software projects cannot meet their planned timescales, functional capabilities, reliability levels and
Witty, Robert W
core  

The effect of device geometry on the performance of a wave energy converter

Communications Engineering
Wave energy presents an excellent opportunity to add much-needed diversification to the global renewable energy portfolio. However, a competitive levelised cost of electricity for wave energy conversion devices is yet to be proven.
Emma C. Edwards, Craig Whitlam, John Chapman, Jack Hughes, Bryony Redfearn, Scott Brown, Scott Draper, Alistair G. L. Borthwick, Graham Foster, Dick K.-P. Yue, Martyn Hann, Deborah Greaves   +11 more
doaj   +1 more source

Vibro-Acoustic Methods in the Condition Assessment of Power Transformers: A Survey

IEEE Access, 2019
It has been over two decades since the publication of pioneer works about the power transformer diagnostics based on monitoring of their acoustic fingerprints. Since then, there has been great progress in this field and the methods used are as complex as
Adnan Secic, Matej Krpan, Igor Kuzle
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Modeling and analysis of resources availability in volunteer computing systems [PDF]

, 2013
Volunteer computing systems are large-scale distributed systems with large number of heterogeneous and unreliable Internet-connected hosts. Volunteer computing resources are suitable mainly to run High-Throughput Computing (HTC) applications due to their
Javadi, Bahman (R17034), Matawie, Kenan M. (R8147), Anderson, David P., Bahman Javadi, Kenan Matawie, David P. Anderson   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Fast Transformation Method of Service Centre Data Model in Power Grid Resource Service

IET Cyber-Physical Systems
In the processing of power grid resource data, incomplete data from service centres lead to data loss, incompleteness, or inaccuracy, which seriously affects the training of neural networks.
Li Chen, Wenyuan Bai, Shaobo Liu, Wei Chen, Jun Wang   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source