Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Development and Application of SONIC Divertor Simulation Code to Power Exhaust Design of Japanese DEMO Divertor [PDF]
, 2022 N. Asakura +4 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Estimation of Wasted Thermal Energy from Gas Turbine Units in Mosul Power Station
Tikrit Journal of Engineering Sciences, 2012 The present study involve a thermal analysis of a gas turbine unit like those which are used in Mosul gas turbine power station in order to estimate the amount of thermal energy is wasted in the exhaust gases.
Dr. A. R. Al-Habbo, A.Youns Fathi
doaj +3 more sources
Experiments on plasma detachment in a V-shaped slot divertor in the DIII-D tokamak
Nuclear FusionExperiments in DIII-D demonstrate that the upstream plasma density to detach an un-pumped slot divertor is similar for a V-shaped and a flat-end slot, despite significantly higher neutral pressure in the V-shaped slot and in contrast to SOLPS-ITER ...
R. Maurizio +14 more
doaj +1 more source
Engine Exhaust Stub Sizing for Turboprop Powered Aircraft [PDF]
, 2023 Chikkanayakanahalli Anand Vinay +2 more
openalex +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Calorimetry measurement for energy balance and energy distribution in WEST for L-mode plasmas
Nuclear FusionThis paper presents the energy balance of 602 pulses from four different experimental campaigns for the WEST tokamak. Different magnetic configurations have been studied, with lower single null (LSN) and upper single null (USN) configuration with ...
J. Gaspar +12 more
doaj +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source