Results 91 to 100 of about 545,803 (316)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Cooperative Model Predictive Control for Distributed Photovoltaic Power Generation Systems
, 2016 In this paper, we investigate a cooperative model predictive control for distributed photovoltaic (PV) power generation systems. A two-level control strategy is proposed.
Wu, Zhipeng +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Vibration and acoustic noise emitted by dry-type air-core reactors under PWM voltage excitation
AIP Advances, 2018 According to coupling way between the magnetic field and the structural order, structure mode is discussed by engaging finite element (FE) method and both natural frequency and modal shape for a dry-type air-core reactor (DAR) are obtained in this paper.
Jingsong Li +5 more
doaj +1 more source
Measurement-based solution for low frequency oscillation analysis
Journal of Modern Power Systems and Clean Energy, 2016 This paper presents a measurement-based solution for low frequency oscillation (LFO) analysis in both real time monitoring and off-line case study. An online LFO property discrimination method is developed first, which alternately uses empirical mode ...
Chen Shen +4 more
doaj +1 more source
Review of automatic generation control in deregulated environment
, 2017 This paper reviews various control methods for design of Automatic Generation Control (AGC) in the deregulated power system environment. The power system models and control techniques/structures that concern the AGC problem design and implementation ...
Krishnamurthy, Senthil +7 more
core +1 more source
Power Extraction Strategy of a Robust kW Range Marine Tidal Turbine Based on Permanent Magnet Synchronous Generators and Passive Rectifiers [PDF]
, 2014 This paper presents a kW range marine tidal current power generation system consisting of a fixed pitch marine current turbine (MCT) with two permanent magnet synchronous generators in the turbine shaft, two diode rectifiers (each rectifier is associated
ODEDELE, Nafissah +5 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source