Results 71 to 80 of about 137,935 (294)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Short-Term Load Forecasting Method Based on Feature Preference Strategy and LightGBM-XGboost

open access: yesIEEE Access, 2022
Short term load forecasting is one of the important problems in power system. Accurate forecasting results can improve the flexibility of power market and resource utilization efficiency, which is of great significance to the efficient operation of power
Xiaotong Yao, Xiaoli Fu, Chaofei Zong
doaj   +1 more source

Local Short Term Electricity Load Forecasting: Automatic Approaches

open access: yes, 2017
Short-Term Load Forecasting (STLF) is a fundamental component in the efficient management of power systems, which has been studied intensively over the past 50 years. The emerging development of smart grid technologies is posing new challenges as well as
Bianchi, Filippo Maria   +2 more
core   +1 more source

The Comparison Study of Short-Term Prediction Methods to Enhance the Model Predictive Controller Applied to Microgrid Energy Management [PDF]

open access: yes, 2017
Electricity load forecasting, optimal power system operation and energy management play key roles that can bring significant operational advantages to microgrids.
Da Costa Mendes, Paulo Renato   +5 more
core   +4 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Short-Term Power Load Forecasting Using Adaptive Mode Decomposition and Improved Least Squares Support Vector Machine

open access: yesEnergies
Accurate power load forecasting is crucial for ensuring grid stability, optimizing economic dispatch, and facilitating renewable energy integration in modern smart grids.
Wenjie Guo, Jie Liu, Jun Ma, Zheng Lan
doaj   +1 more source

Review of Smart Meter Data Analytics: Applications, Methodologies, and Challenges

open access: yes, 2018
The widespread popularity of smart meters enables an immense amount of fine-grained electricity consumption data to be collected. Meanwhile, the deregulation of the power industry, particularly on the delivery side, has continuously been moving forward ...
Chen, Qixin   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

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