Results 81 to 90 of about 9,504 (261)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Power short-term load forecasting based on big data and optimization neural network

Tongxin xuebao, 2016
With the reduction of the cost of power data acquisition and the interconnection of large scale power systems,the types of data available in the power network are becoming more and more abundant.In the past,the centralized fore-casting method was limited
Xin JIN, Long-wei LI, Jia-nan JI, Zhi-qi LI, Yu HU, Yong-bin ZHAO   +5 more
doaj   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Short-term Electricity Load Forecasting Based on Improved Seagull Algorithm Optimized Gated Recurrent Unit Neural Network

EAI Endorsed Transactions on Energy Web
INTRODUCTION: The complexity of the power network, changes in weather conditions, diverse geographical locations, and holiday activities comprehensively affect the normal operation of power loads.
Mengfan Xu, Junyang Pan
doaj   +1 more source

Power policy quantification based on PMC index model and its application in load forecasting

智能科学与技术学报, 2021
Policy has a direct impact on power system load.In order to fully explore the relationship between policy factors and load, and improve the accuracy of load forecasting, a quantitative method of power policy based on policy modeling consistency (PMC ...
Tianbin LIU, Hang ZHAO, Chen WANG, Hongxia YUAN, Yinya ZHANG, Chenxi HU, Jinxing LI, Tianlu GAO, Jun ZHANG   +8 more
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Weekend Load Forecasting Model Based on Semi-Parametric Regression Analysis Considering Weather and Load Interaction

Energies, 2019
Compared to the load characteristics of normal working days, weekend load characteristics have a low level of load and are sensitive to meteorological conditions, which influences the accuracy of short-term weekend-load forecasting. To solve this problem
Bin Li, Mingzhen Lu, Yiyi Zhang, Jia Huang   +3 more
doaj   +1 more source