Results 61 to 70 of about 1,542,691 (303)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
OPTIMAL LOSSES IN POWER DISTRIBUTION NETWORKS
Известия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2014 The distributed power network 0,38–10 kV is investigated and the conditions for providing optimal load of network and technically reasonable (minimal) values of electricity consumption are determined.
M. I. Fursanov
doaj
Multipulse current source offers low power losses and high reliability [PDF]
, 1967 Pulse current source uses low loss, high reliability, LC circuits to provide the necessary high impedance for magnetic memory cores, frequently used in digital computational equipment.
core +1 more source
Dissipative breathers in rf SQUID metamaterials [PDF]
, 2009 The existence and stability of dissipative breathers in rf SQUID (Superconducting Quantum Interference Device) arrays is investigated numerically. In such arrays, the nonlinearity which is intrinsic to each SQUID, along with the weak magnetic coupling of
Eleftheriou, Maria +2 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Investigation of the Heating Processes and Temperature Field of the Frequency-controlled Asynchronous Engine Based on Mathematical Models [PDF]
, 2019 The study of the temperature field of the engine for non-stationary modes is done. A numerical simulation of a non-stationary thermal process using dynamic EHD, the characteristic of the rate of rise of temperatures is done.
Dulfan, S. (Sergii) +2 more
core +3 more sources
Power loss mechanisms in pathological tracheas
Journal of Biomechanics, 2016 The effort required to inhale a breath of air is a critically important measure in assessing airway function. Although the contribution of the trachea to the total flow resistance of the airways is generally modest, pathological alterations in tracheal geometry can have a significant negative effect.
Bates, A.J. +5 more
openaire +4 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source