Results 61 to 70 of about 180,098 (263)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Evaluation of Electric Energy Losses in Kirkuk Distribution Electric System Area [PDF]

open access: yesIraqi Journal for Electrical and Electronic Engineering, 2011
Correct calculations of losses are important for several reasons. There are two basic methods that can be used to calculate technical energy losses, a method based on subtraction of metered energy purchased and metered energy sold to customers and a ...
Sameer S. Mustafa   +2 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Analysis of Critical Power Loss in a Superconductor [PDF]

open access: yesJournal of Applied Physics, 1971
A critical power dissipation resulting from an oscillating magnetic field, Hp cosωt, can produce a magnetic breakdown field, Hp′ < Hc, the critical field of the superconductor. The analysis shows, for example, why the breakdown field of a superconducting microwave cavity can be well below Hc in some cases, and indicates what the functional ...
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Methods of reducing power losses in distribution systems

open access: yesMATEC Web of Conferences, 2017
The object of research is plot of an urban electricity distribution network of 10/0.4 kV of Tomsk city. The purpose of work – research and development of scientific and technical solutions to optimize the plot operation modes of an urban power supply ...
Wilms Yakov   +2 more
doaj   +1 more source

Stochastic Stability Analysis of the Power System with Losses

open access: yesEnergies, 2018
Renewable energy and electric vehicles have become involved in power systems, which has attracted researchers to stochastic continuous disturbances (SDEs).
Hongyu Li   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

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