Results 41 to 50 of about 5,444,667 (257)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A state-of-art review on SiC power module packaging and thermal management key technologies
机车电传动, 2023 Silicon carbide (SiC) power devices have advantages such as high withstanding voltage, fast switching speed, and low conduction losses. Therefore, they are gradually becoming core components of power conversion systems, especially in areas such as new ...
SHENG Kuang, TANG Weiyu, WU Zan
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
PV Balancer --Concept, Architectures and Realization [PDF]
, 2012 This thesis presents a new concept of module-integrated converters called PV balancers for photovoltaic applications. The proposed concept enables independent maximum power point tracking (MPPT) for each panel, and dramatically decreases the requirements
Zhou, Huimin
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Optimized Design of Side-Connected Rectified Planar Transformer for Data Center DCX Modules
EnergiesThe rapid advancement of artificial intelligence (AI) has continuously boosted the computing power of data centers, imposing stringent requirements on the efficiency and power density of low-voltage high-current power modules.
Yang Cao +4 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Thermal Design and Simulation of 1 500 A/3 300 V IGBT Power Modulein Traction Applications
机车电传动, 2013 The thermal management of 1 500 A/3 300 V IGBT power module was developed in this paper. First, based on thermal nodes network, an equivalent circuit model for thermal resistance of power module was highlighted, from which the steady state thermal ...
LIU Guo-you +3 more
doaj
Red Guide Paper 42: Managing a Module Part 1: Delivering a Module [PDF]
, 2008 This revised guide covers various aspects of the process for developing a new module and provides an overview of the general principles of module ...
Smailes, Joanne +2 more
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