Results 41 to 50 of about 2,841,897 (254)
Energies, 2020 One or more isothermal heating process was introduced to modify single and regenerative Brayton cycles by some scholars, which effectively improved the thermal efficiency and significantly reduced the emissions. To analyze and optimize the performance of
Lingen Chen +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Frontiers in PhysiologyIntroductionHigher work rates may be sustainable when maintaining target rating of perceived exertion (RPE) compared to maintaining target heart rate (THR) during high-intensity interval training (HIIT) exercise in hot conditions, but may also result in ...
Hillary A. Yoder +5 more
doaj +1 more source
Examining the Efficiency of Electric-Assisted Mountain Biking across Different Types of Terrain
Applied Sciences, 2023 Mountain bikes with electric assistance (e-bikes) have gained popularity recently by allowing riders to increase their pedaling power through an electric motor.
Samo Rauter, Matej Supej, Janez Vodičar
doaj +1 more source
Output characteristics of tidal current power stations [PDF]
, 2004 With increasing targets being set for renewable-derived electricity generation, wind power is currently the preferred technology. It is widely accepted that due to the stochastic nature of wind, there is an upper limit to the capacity that can be ...
Clarke, Joseph Andrew +2 more
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