Results 61 to 70 of about 1,237,786 (296)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Voltage stability assessment for distrbuted generation in islanded microgrid system [PDF]

open access: yes, 2012
The increasing energy demands are stressing the generation and transmission capabilities of the power system. Distributed generation (DG), which generally located in distribution systems, has the ability to meet some of the growing energy demands ...
Hendi Gareh, Saleh Ali Ahmed
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Improvement of damping characteristics and index evaluation of a wind-PV-thermal-bundled power transmission system by combining PSS and SSSC

open access: yesArchives of Electrical Engineering, 2020
The grid integration of large-scale wind and solar energy affects the power flow of wind-PV-thermal-bundled power transmission systems and may introduce an unpredicted threat to the power system’s small signal stability.
Ping He   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Frequency regulation controller for multi‐area interconnected power system

open access: yesIET Generation, Transmission & Distribution
By increasing the number of electric vehicles (EVs) to achieve a less carbon environment, not only they consume power from the grid to be charged, but also do they deliver power to the grid, and this can play a significant role in load frequency control.
Sajjad Malek   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Gradient descent based dynamic optimization for VSG dominated microgrid

open access: yesThe Journal of Engineering
As the integration of distributed generation units into the power grid continues to grow, the system becomes increasingly vulnerable to power fluctuations and potential failures, which significantly challenge grid stability.
Yan Li   +5 more
doaj   +1 more source

Power System Stability Analysis Considering Dynamic Loads

open access: yesJournal of the Korea Academia-Industrial cooperation Society, 2012
In this paper, we have simulated the transient stability of power system with dynamic loads. Dynamic load characteristics have an important influence on power system stability. In study of power system stability, motors form a major portion of the system loads.
Gyu-Seok Seo, Ji-Ho Park, Ki-Jin Kwon
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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