Results 81 to 90 of about 286,515 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Novel Power Transformer Condition Monitoring System Based on Wide-Band Measurement of Core Earth Signals and Correlation Analysis With Multi-Source Data

IEEE Access, 2019
On-line condition monitoring and real-time fault detection are essential to protect power transformers from unscheduled outage of services. The core earth signals (CES) are valuable for fault detection and diagnosis of power transformers, as they are ...
Xuezhi Ke, Lisheng Pang, Xiang Dong, Zhaohui Li   +3 more
doaj   +1 more source

Transient fault area location and fault classification for distribution systems based on wavelet transform and Adaptive Neuro-Fuzzy Inference System (ANFIS) [PDF]

, 2018
A novel method to locate the zone of transient faults and to classify the fault type in Power Distribution Systems using wavelet transforms and Adaptive Neuro-Fuzzy Inference Systems (ANFIS) has been developed.
Ghazizadeh-Ahsaee, Mahdi, Khaleghi, Ali, Rabori, Alireza Mehdipour, Sadegh, Mahmoud Oukati   +3 more
core   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

A Comparison of Inverse Simulation-Based Fault Detection in a Simple Robotic Rover with a Traditional Model-Based Method [PDF]

, 2017
Robotic rovers which are designed to work in extra-terrestrial environments present a unique challenge in terms of the reliability and availability of systems throughout the mission. Should some fault occur, with the nearest human potentially millions of
Flessa, Thaleia, Ireland, Murray L., Mackenzie, Rebecca, McGookin, Euan, Thomson, Douglas, Worrall, Kevin J.   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Transient Stability Improvement of Power System by Assigning Dynamic Converter Limits to Superconducting Magnetic Energy Storage

IET Energy Systems Integration
The virtual synchronous generator (VSG) concept is implemented to mimic the properties of synchronous generators and therefore improve the stability of modern power systems.
Abdul Waheed Kumar, Mairaj Ud‐Din Mufti, Mohd Hasan Ali   +2 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Ground fault protection algorithm of active distribution network based on energy extremum direction

IET Generation, Transmission & Distribution
After large‐scale distributed power sources are connected to the distribution network, the fault current undergoes noticeable changes, affecting the accuracy of traditional single‐phase grounding fault algorithms.
Li Jun, He Min, Huang Shoudao, Wu Xuan, Fan lv, Liu Zhi Yong   +5 more
doaj   +1 more source