Results 41 to 50 of about 78,720 (302)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A domain adaptation‐based convolutional neural network incorporating data augmentation for power system dynamic security assessment

The Journal of Engineering
Recently, deep learning (DL) based dynamic security assessment (DSA) methods have been very successful. However, although a DSA model can be trained well for a specific topology, it often does not perform well for other topologies.
Sasan Azad, Mohammad Taghi Ameli
doaj   +1 more source

Recognition of transient instability scenarios of the receiving-end grid and control strategy optimization

Zhejiang dianli, 2023
Under the influences of AC-DC coupling， uncoordinated network-source development， and new energies that fail to meet the demand of grid-related performance， power system stability is becoming a point of extreme gravity. The correlation characteristics of
WANG Bowen, WANG Longfei, DONG Wei, ZHUO Guying, HUA Wen, SHENTU Leixuan   +5 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Impact of the power-controlled static synchronous machine on transient stability of power system

Frontiers in Energy Research
Compared with the grid-following (GFL)-converter-interfaced generations (CIG), the power-controlled static synchronous machine (PCSSM) can realize voltage and frequency control through the power tracking function, which has the potential to improve the ...
Liu Qing, Zhang Zheren, Xue Yicheng, Xu Zheng   +3 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Transient Stability Analysis and Improvement of Multi-paralleled Power Conversion System Based on the Lyapunov’s Direct Method

Human-Centric Intelligent Systems
The objective of this study is to analyze the transient stability of a multiparalleled grid-forming (GFM) power conversion system (PCS) under grid fault conditions.
Liu Hongyan, Ouyang Xia, Wu Jisi, Liu Qi
doaj   +1 more source

Transient Stability Assessment Method for Multi-machine Power Systems Considering Dense Channels

Zhongguo dianli
To improve the accuracy and efficiency of power system transient stability assessment, a transient stability assessment method for multi-machine power system considering dense channel based on deep transfer is proposed. Firstly, a new transient stability
Xuejun WANG, Shuiping FANG, Guangyong CHI   +2 more
doaj   +1 more source

Agent Based Power System Transient Stability Enhancement

, 2012
This paper describes an intelligent agent approach to power system fault diagnosis during disturbance condition for the enhancement of the transient stability with better coordination of protection devices using auto-reclosing technique.
M. S. Rahman, Rahman, MS, Pota, HR, H. R. Pota, Hossain, Jahangir, Rahman, M., Pota, H., Hossain, MJ, M. J. Hossain   +8 more
core   +1 more source