Results 51 to 60 of about 72,767 (263)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Estimating the region of attraction of wind integrated power systems based on improved expanding interior algorithm

IET Generation, Transmission & Distribution
This paper proposes an improved expanding interior algorithm (EIA) to estimate the region of attraction (ROA) of power systems with wind power generation based on sum of squares (SOS) programming.
Yang Liu, Huanjin Yao, Zengjie Chen, Xiangyu Pei, Yuexi Yang, Qinghua Wu   +5 more
doaj   +1 more source

Optimal operation of power systems constrained by transient stability

Electrical Engineering in Japan, 2000
AbstractOptimal power flow (OPF) with transient stability constraints is a nonlinear optimization problem in functional space that is not easy to deal with precisely even for small‐scale power systems. Instead of directly tackling this tricky problem, in this paper, OPF with transient stability constraints (OTS) is equivalently converted into an ...
Luonan Chen, Asako Ono, Yasuyuki Tada, Hiroshi Okamoto, Ryuya Tanabe   +4 more
openaire   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Transient Stability Hierarchical Control in Multimachine Power Systems

IEEE Power Engineering Review, 1989
The authors present the optimal transient stability control problem in a hierarchical structure for multimachine power systems. The two-level structure retains the local closed-loop controls, thereby easing its implementation on existing systems. The formulation accounts for nonlinearities and interconnections, and the optimization of the system ...
A. Rubaai, F.E. Villaseca
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Stability of Power Grids: State-of-the-art and Future Trends [PDF]

EPJ Web of Conferences, 2019
The state of the art of transient stability and steady-state (small signal) stability in power grids are reviewed. Transient stability concepts are illustrated with simple examples; in particular, we consider two machine learning-based methods for ...
Tomin Nikita, Panasetsky Daniil, Iskakov Alexey   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Transient stability analysis of wind-thermal bundled system based on virtual inertia control

The Journal of Engineering, 2019
In this study, the transient stability characteristics of the wind-thermal bundled system is discussed when the wind turbine adopts the additional control of virtual inertia.
Yao Shujun, Guo Wanhua, Huang Wenerda, Xu Hongtao, Bian Erman   +4 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source