Results 111 to 120 of about 35,470,184 (340)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Evaluation of conventional power systems [PDF]
The technical, economic, and environmental characteristics of (thermal, nonsolar) electric power plants are reviewed. The fuel cycle, from extraction of new fuel to final waste management, is included.
Holdren, J. P., Smith, K. R., Weyant, J.
core +1 more source
Characterizing PSPACE with Shallow Non-Confluent P Systems [PDF]
, 2018 In P systems with active membranes, the question of understanding the power of non-confluence within a polynomial time bound is still an open problem.
Leporati, Alberto +4 more
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Ion flow characteristic under UHVDC transmission line at high altitude
The Journal of Engineering, 2018 Among the electromagnetic environment parameters, corona current is of great significance to the evaluation of the state of the power system. However, there are few studies on the corona characteristics of high altitude transmission lines at home and ...
Mou Ya +5 more
doaj +1 more source
Fault Current Limiters in Power Systems: A Comprehensive Review
, 2018 Power systems are becoming more and more complex in nature due to the integration of several power electronic devices. Protection of such systems and augmentation of reliability as well as stability highly depend on limiting the fault currents.
Alam, M. Abido, I. El-Amin
semanticscholar +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source