Results 41 to 50 of about 9,920 (210)

Vaccinia virus and Cowpox virus are not susceptible to the interferon-induced antiviral protein MxA. [PDF]

PLoS ONE, 2017
MxA protein is expressed in response to type I and type III Interferon and constitute an important antiviral factor with broad antiviral activity to diverse RNA viruses.
María M Lorenzo, Juana M Sanchez-Puig, Rafael Blasco   +2 more
doaj   +1 more source

Polymerase chain reaction detection of avipox and avian papillomavirus in naturally infected wild birds: comparisons of blood, swab and tissue samples [PDF]

, 2014
Avian poxvirus (avipox) is widely reported from avian species, causing cutaneous or mucosal lesions. Mortality rates of up to 100% are recorded in some hosts. Three major avipox clades are recognized.
Buller R., Clara Escudero Duch, Hansen W., Howley P., Javier Pérez-Tris, Laura Benítez, Richard A. J. Williams, Saijo M., Sambrook J., Tripathy D.   +9 more
core   +3 more sources

Machine Learning‐Augmented Loop‐Mediated Isothermal Amplification‐Enabled Point‐of‐Care for Mpox‐Specific Detection

Advanced Intelligent Systems, EarlyView.
A low‐cost, portable point‐of‐care platform for rapid Mpox detection using loop‐mediated isothermal amplification is reported. The device integrates fluorescence readout and mobile monitoring. A machine‐learning model analyzes temperature data and correlates thermal changes with DNA concentration, enabling sensitive and reliable molecular diagnosis in ...
Nazente Atceken, Ahmed Choukri Abdullah, Olgac Ozarslan, Ziya Yıldız, Savas Tasoglu   +4 more
wiley   +1 more source

Evolutionary History and Attenuation of Myxoma Virus on Two Continents [PDF]

, 2012
The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence.
Adam Fitch, Andrew F. Read, Bruce R. Levin, David C. Tscharke, Edward C. Holmes, Elodie Ghedin, Isabella M. Cattadori, Jay V. DePasse, Peter J. Hudson, Peter J. Kerr   +9 more
core   +5 more sources

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

Animal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei, Jing Wu, Hekai Yang, Na Li, Binbin Zhao, Wanjun Peng, Na Rong, Wei Zhang, Jing Xue, Jiangning Liu   +9 more
wiley   +1 more source

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5 [PDF]

, 2011
The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs.
A Ghosh, A Nomoto, A Pichlmair, AM Waterhouse, B Morin, Benjamin W Neuman, BS Schnierle, Burkhard Ludewig, CA Janeway Jr., DJ Hui, E Decroly, EJ Snijder, F Terenzi, G Bocharov, G Uzé, H Hemmi, H Kato, H Zhou, J Reguera, JK Roth-Cross, John Ziebuhr, K Bryson, K Karikó, KK Eriksson, KM Rose, Kristy J Szretter, L Cervantes-Barragan, L Cervantes-Barragán, L Gitlin, Luisa Cervantes-Barragan, M Bouvet, M Feder, M Schlee, Matthias Habjan, Michael S Diamond, O Haller, O Le Gall, O Takeuchi, R Gosert, R Züst, Reinhard Maier, Roland Züst, S Daffis, S Shuman, S Wünschmann, SR Nallagatla, SR Nallagatla, Stuart G Siddell, Susan C Baker, V Hornung, V Thiel, Volker Thiel, Winfried Barchet, Y Chen, YM Loo, YM Loo   +55 more
core   +1 more source

Treatments for Molluscum contagiosum: A systematic review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Molluscum contagiosum (MC) is a viral skin infection that poses significant physical and psychosocial burdens, particularly in pediatric and immunocompromised populations. Despite the availability of various treatment options, comparative efficacy and safety data remain limited.
Ou Jia (Emilie) Wang, Mahek Shergill, Ammar Saed Aldien, Ilya Mukovozov   +3 more
wiley   +1 more source

Multiple-Genome Annotation of Genome Fragments Using Hidden Markov Model Profiles [PDF]

, 2008
To learn more about microbes and overcome the limitations of standard cultured methods, microbial communities are being studied in an uncultured state. In such metagenomic studies, genetic material is sampled from the environment and sequenced using the ...
Baek, K., Menor, M., Poisson, G.
core  

Fish Poxviruses on the Rise: Prospects for Aquatic Health

Journal of Fish Diseases, EarlyView.
ABSTRACT Fish poxviruses are increasingly recognised as emerging pathogens of fish and should be considered in cases of unexplained gill or skin pathology. Carp edema virus (CEV), the causative agent of koi sleepy disease in common carp and koi (Cyprinus carpio), represents the first known example.
Mikolaj Adamek, Marek Matras, Oluwaseun Christianah Ojelade, Motohiko Sano, Mona C. Gjessing, Tomas Korytar, Alberto Falco, Krzysztof Rakus, Verena Jung‐Schroers, Andor Doszpoly   +9 more
wiley   +1 more source