Results 1 to 10 of about 11,852 (137)

Effects of Passiflora incarnata Leaf Polyphenol Extract on High-Fat-Diet-Induced Metabolic Syndrome in Mice and Associated Changes in the Gut–Liver–Adipose Axis [PDF]

Foods
Metabolic syndrome, driven by obesity, poses a significant global health burden. P. incarnata leaf polyphenol extract (PP), a crude 70% ethanol extract, exhibits potential bioactive properties, yet its efficacy and underlying mechanisms against metabolic
Ying Ju, Liangliang Qi, Yongcai Huang, Ge Chen, Jie Gui, Xuzhou Liu, Liu Yang   +6 more
doaj   +2 more sources

AMPK–PP1/PP2 axis regulates GSDMD-mediated pyroptosis via phosphorylation [PDF]

Frontiers in Oncology
Gasdermin D (GSDMD), the most important executor of pyroptosis, is activated through caspase cleavage to release the N-terminal fragment (GD-NT), which oligomerizes and forms pores in the plasma membrane to induce pyroptosis.
Ting Zhang, Ting Zhang, Chunxiao Gao, Chunxiao Gao, Jixuan Xu, Weishan Zhang, Yamin Xing, Guangyuan Li, Guangyuan Li, Mengxue Li, Yanwei Guo, Yanwei Guo, Zisen Zhang, Zisen Zhang, Pengyuan Zheng, Xiaoke Zheng, Xiaoke Zheng, Xiufeng Chu, Xiufeng Chu, Xiufeng Chu, Xiufeng Chu   +20 more
doaj   +2 more sources

Fasting serum annexin A2 is associated with peripheral insulin sensitivity and may enhance glucose uptake via Src-dependent signaling. [PDF]

J Diabetes Investig
Circulating Annexin A2 is positively associated with peripheral insulin sensitivity. ABSTRACT Background and Aim Subcellular annexin A2 (ANXA2) is known to regulate membrane dynamics and GLUT4 trafficking in adipocytes; however, the role of serum ANXA2 in glucose metabolism remains unclear.
Ito Y, Okura T, Anno M, Kitao S, Endo S, Ichihara Y, Sawano T, Miake J, Ueta E, Kato M, Taniguchi SI, Yamamoto K, Imamura T.   +12 more
europepmc   +2 more sources

In-Planta Assay of Culture Filtrate Concentration of Trichoderma viride PP2 as Biocontrol Agent Against Colletotrichum gloeosporioides in Red Chili Pepper Cabai (Capsicum annuum Linnaeus)

Jurnal Proteksi Tanaman, 2021
The culture filtrate is a secondary metabolite produced from the multiplication of fungi in a liquid medium during the incubation period, separated between the fungal cell and their supernatants.
Gefi Zulmiati Lannur, Yenni Liswarni, Martinius Martinius   +2 more
doaj   +1 more source

A systematic analysis of the phloem protein 2 (PP2) proteins in Gossypium hirsutum reveals that GhPP2-33 regulates salt tolerance

BMC Genomics, 2023
Background Phloem protein 2 (PP2) proteins play a vital role in the Phloem-based defense (PBD) and participate in many abiotic and biotic stress. However, research on PP2 proteins in cotton is still lacking.
Fei Wei, Pengyun Chen, Hongliang Jian, Xiaohao Guo, Xiaoyan Lv, Boying Lian, Mengxi Sun, Li An, Xinyu Dang, Miaoqian Yang, Hongmei Wu, Nan Zhang, Aimin Wu, Hantao Wang, Liang Ma, Xiaokang Fu, Jianhua Lu, Shuxun Yu, Hengling Wei   +18 more
doaj   +1 more source

Prooxidant and antioxidant processes in the liver homogenate of healthy and tumor-bearing mice under the action of thiazole derivatives [PDF]

The Ukrainian Biochemical Journal, 2021
Thiazole derivatives were shown to have toxic effects in vitro on cancer cells of different origin and can be considered as potentially antineoplastic, but their effect on the normal tissues needs to be studied.
Ya. R. Shalai, M. V. Popovych, S. M. Mandzynets, V. P. Hreniukh, N. S. Finiuk, A. M. Babsky   +5 more
doaj   +1 more source

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor

Cells, 2020
The SRC kinase family comprises non-receptor tyrosine kinases that are ubiquitously expressed in all cell types. Although Src is reportedly activated in pulmonary and renal fibrosis, little is known regarding its role in liver fibrosis.
Hye-Young Seo, So-Hee Lee, Ji-Ha Lee, Yu Na Kang, Jae Seok Hwang, Keun-Gyu Park, Mi Kyung Kim, Byoung Kuk Jang   +7 more
doaj   +1 more source

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway

Biology Open, 2020
The morbidity and mortality of primary liver cancer is one of the highest amongst all cancers. Deficiency of effective treatment and characteristics of cancer metastasis are believed to be responsible for this situation, thus a great demand is required ...
Dejiang Pang, Chengcheng Yang, Chao Li, Yuanfeng Zou, Bin Feng, Lixia Li, Wentao Liu, Qihui Luo, Zhengli Chen, Chao Huang   +9 more
doaj   +1 more source

Downregulation of Src Family Kinase Activity Using PP2 Inhibitor Has No Effect on the Elongation of Pragmin-Transfected Adenocarcinoma AGS cells [PDF]

International Journal of Basic Science in Medicine, 2018
Introduction: Pragmin is the first mammalian protein that contains a functional the Glu-ProIle-Tyr-Ala (EPIYA) motif. Pragmin is tyrosine-phosphorylated at EPIYA motif by Src family kinases (SFKs), C-terminal Src kinase (CSK), and in response to ...
Fatemeh Safari, Sheida Jodayri Zayer
doaj   +1 more source

Src Activation Aggravates Podocyte Injury in Diabetic Nephropathy via Suppression of FUNDC1-Mediated Mitophagy

Frontiers in Pharmacology, 2022
Background and purpose: Mitophagy plays a significant role in the progression of diabetic nephropathy (DN), although the regulatory mechanisms remain unclear. Recently, accumulating evidence demonstrated that impaired mitochondrial function and mitophagy
Ting Zheng, Han-yu Wang, Yang Chen, Xiao Chen, Zi-ling Wu, Qin-yu Hu, Hui Sun   +6 more
doaj   +1 more source