Results 51 to 60 of about 14,919 (212)

RETRACTED ARTICLE: Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury

Respiratory Research, 2014
Background Ventilator-induced lung injury (VILI) is characterized by increased alveolar permeability, pulmonary edema. The tyrosine kinase, c-Src, is involved in VILI but its role has not been fully elucidated.
Tao Zhao, Mengjie Liu, Changping Gu, Xin Wang, Yuelan Wang   +4 more
doaj   +1 more source

p38 Mitogen-Activated Protein Kinase Contributes to Angiotensin II-Stimulated Migration of Rat Aortic Smooth Muscle Cells

Journal of Pharmacological Sciences, 2007
In this study, we clarified the intracellular mechanism of angiotensin II (Ang II) in promoting migration in rat aortic smooth muscle cells (RASMCs). RASMC migration was measured with the Boyden chamber assay, and the result was confirmed with an aortic ...
Hwan Myung Lee, Chang-Kwon Lee, So Hee Lee, Hui Yul Roh, Young Min Bae, Kyung-Yung Lee, Jaegeun Lim, Pyo-Jam Park, Tae-Kyu Park, Yun Lyul Lee, Kyung-Jong Won, Bokyung Kim   +11 more
doaj   +1 more source

Oligogenic inheritance in epilepsy: A systematic exome‐wide analysis

Epilepsia, EarlyView.
Abstract Objective Genetic factors contribute to the majority of epilepsies, but the exact genetic cause remains unknown in most patients. Incomplete penetrance and variable expressivity are frequent, and recent studies showed a burden of deleterious variants in epilepsy genes, suggesting a role for oligogenic inheritance.
Sarah Duerinckx, Barbara Gravel, Julie Soblet, Benjamin Legros, Susana Ferrao Santos, Wim Van Paesschen, Estelle Rikir, Epi25 Collaborative, Siwei Chen, Zaid Afawi, Quratulain Zulfiqar Ali, Danielle M. Andrade, Mutluay Arslan, Simona Balestrini, Carmen Barba, Tobias Baumgartner, Betül Baykan, Nerses Bebek, Felicitas Becker, Caitlin A. Bennett, Ahmad Beydoun, Francesca Bisulli, Christian Bosselmann, S. Hande Caglayan, Laura Canafoglia, Barbara Castellotti, Francine Chassoux, I‐Jun Chou, Seo‐Kyung Chung, Patrick Cossette, Chantal Depondt, Orrin Devinsky, Dennis J. Dlugos, Viola Doccini, Colin A. Ellis, Thomas N. Ferraro, Lorenzo Ferri, Mark Fitzgerald, Francesco Fortunato, Elena Freri, Tania Giangregorio, Tracy A. Glauser, Aslı Gundogdu‐Eken, Namrata Gupta, Kevin Haas, Erin L. Heinzen, Christian Hengsbach, Olivia Hoeper, Michele Iacomino, Yushi Inoue, Lara Jehi, Symon M. Kariuki, Karl Martin Klein, Susanne Knake, Andreas Koupparis, Ioanna Kousiappa, Roland Krause, Martin Krenn, Heinz Krestel, Wolfram S. Kunz, Austin Lacey, Stephan Lauxmann, Stephanie L. Leech, Gaetan Lesca, David Lewis‐Smith, Calwing Liao, Laura Licchetta, Kuang‐Lin Lin, Tarja Linnankivi, Daniel H. Lowenstein, Colin H.T. Lui, Ida Manna, Paula Marques, Patrick May, Davide Mei, RaAaella Minardi, Barbara Mostacci, Lorenzo Muccioli, Bernd A. Neubauer, Terence J. O'Brien, Savvas S. Papacostas, Elena Parrini, Manuela Pendziwiat, Francesca Ragona, Mark I. Rees, Antonella Riva, Philippe Ryvlin, Andrea Salmon, Ilaria Sammarra, Marcello Scala, Ingrid E. ScheAer, Susanne Schubert‐Bast, Paolo Scudieri, Graeme J. Sills, Sanjay M. Sisodiya, Hannah Stamberger, Ulrich Stephani, Carlotta Stipa, Pasquale Striano, Adam Strzelczyk, Rainer Surges, Toshimitsu Suzuki, Mariagrazia Talarico, George A. Tanteles, Marian Todaro, Meng‐Han Tsai, Birute Tumiene, Dilsad Turkdogan, Luc Valton, Andreas van Baalen, Annalisa Vetro, Yvonne G. Weber, Sarah Weckhuysen, Peter Widdess‐Walsh, Samuel Wiebe, Randi von Wrede, Kazuhiro Yamakawa, Zuhal Yapıcı, Fritz Zimprich, Milena Zizovic, Gábor Zsurka, Benjamin M. Neale, Samuel F. Berkovic, Solve‐RD DITF‐EpiCARE, Marc Abramowicz, Nicholas Allen, Simona Balestrini, Tobias Bartolomaeus, Ravishankara Bellampalli, Katherine Benson, Francesca Bisulli, Christian Boßelmann, Susan Byrne, Laura Canafoglia, Evelina Carapancea, Barbara Castellotti, Gianpiero Cavalleri, Roberta Cilio, Norman Delanty, Christel Depienne, Chantal Depondt, Sarah Duerinckx, Zakaria Eddafir, Kornelia Ellwanger, Silvana Franceschetti, Elena Freri, Hamidah Ghani, Tiziana Granata, Marie Greally, Renzo Guerrini, Tobias B. Haack, Eva Hammar Bouveret, Michele Iacomino, Rami Jamra, Josua Kegele, Christian Korff, Roland Krause, Alma Küchler, Robert Lauerer‐Braun, Damien Lederer, Elsa Leitão, Holger Lerche, Gaëtan Lesca, David Lewis‐Smith, Laura Licchetta, Frédéric Masclaux, Patrick May, Davide Mei, Cyril Mignot, Charissa Millevert, Raffaella Minardi, Patrick Moloney, Hiltrud Muhle, Mary O. Reghan, Joohyun Park, Elena Parrini, Manuela Pendziwiat, Konrad Platzner, Johanna Pohl, Mary Sandrine, Marcello Scala, Sanjay Sisodiya, Noor Smal, Hannah Stamberger, Pasquale Striano, Roxane van Heurck, Christina Vosseler‐Wolf, David Webb, Sarah Weckhuysen, Federico Zara, Alec Aeby, Guillaume Smits, Chantal Depondt   +192 more
wiley   +1 more source

Plots of pp2 length/pp5 length and pp3 length/pp4.

, 2012
A, Bivariate plot of pp2/pp5 length and pp3/pp4 length: closed circles (anthropoids); closed triangles (tarsiiforms); closed diamonds (lorises); open diamonds (galagos); open circles (lemuroids); closed octagon (Notharctus); closed star (Darwinius ...
Stephanie Maiolino (188844), Christopher C. Gilbert (136574), Jonathan I. Bloch (188848), Joseph Groenke (188850), Doug M. Boyer (188846)   +4 more
core   +1 more source

Effekte des synthetischen Src-Tyrosinkinaseinhibitors PP2 auf die intestinale Mikrozirkulation während experimenteller Endotoxinämie am Tiermodell Ratte [PDF]

, 2018
Das klinische Bild der Sepsis, des septischen Schockes und des Multiorganversagens sind nach wie vor Krankheitsbilder, wie sie auf Intensivstationen vorzufinden sind und häufig mit einer hohen Letalität assoziiert sind. Die Störung bzw.
Lütche, Stefan
core   +1 more source

Development of Multiplex PCR for Simultaneous Detection of Citrus Viruses and the Incidence of Citrus Viral Diseases in Late-Maturity Citrus Trees in Jeju Island

The Plant Pathology Journal, 2017
Satsuma dwarf virus (SDV) or Citrus mosaic sadwavirus (CiMV) were not consistently detected in RT-PCR assay with the primer sets based on gene of Japan isolates.
Jae Wook Hyun, Rok Yeon Hwang, Kyung Eun Jung   +2 more
doaj   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Inhibition of c-Src activity in astrocytes by PP2.

, 2012
Astrocytes were preincubated with 100 ng/µL PP2 (c-Src inhibitor) or 100 ng/µL PP3 (inactive analogue) for 1 h and these agents were maintained for the rest of the experiment.
José M. Medina (181388), José Carlos Valle-Casuso (181382), Ana González-Sánchez (181386), Arantxa Tabernero (181390)   +3 more
core   +1 more source

Depression Beyond the 6‐Month Postpartum Period: A Mixed‐Method Study Among Women in Nepal

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim This study aimed to comprehensively examine social and clinical factors contributing to postpartum depression among women in Nepal and identify their perspectives/experiences regarding postpartum mental health. Design and Methods The explanatory sequential mixed‐method study was conducted in two phases. In the quantitative phase, data were
Sangita Pudasainee‐Kapri, Tumla Shrestha, Mary Wunnenberg, Kul Kapri, Apsara Pandey, Manisha Chapagai, Ram Hari Chapagain, Pradeep Gupta   +7 more
wiley   +1 more source

Imaging of PP2-A1:GFP and free GFP in the phloem cells of a four-week-old leaf.

, 2015
Visualization of soluble GFP or PP2-A1 tagged with GFP or CFP in leaves from pSUC2:PP2-A1:GFP, pSUC2:PP2-A1:GFP, pSUC2:PP2-A1:CFP and pSUC2:GFP plants. Images were obtained by CLSM and fluorescence is shown in false colors.
Frédéric Revers (158609), Rozenn Le Hir (695779), Thibaud Cayla (695778), James A. Anstead (119389), Sylvie Dinant (695781), Olivier Grandjean (695780), Brigitte Batailler (123894), Gary A. Thompson (119391)   +7 more
core   +1 more source