Results 211 to 220 of about 35,429 (234)

PP2A to Alzheimer’s rescue

Science Signaling, 2016
Transgenic mice with altered methylation of PP2A reveal a new strategy for treating Alzheimer’s disease.
Sudhakaran Prabakaran, Nancy R. Gough
openaire   +1 more source

Shugoshin and PP2A, shared duties at the centromere

BioEssays, 2006
AbstractSister chromatid cohesion mediated by the ring‐shaped cohesin complex is essential for faithful chromosome segregation. A tight spatial and temporal control of cohesin release is observed in mitosis and meiosis, and a family of proteins known as shugoshins play a major role in this process.
Teresa, Rivera, Ana, Losada
openaire   +2 more sources

The Role of PP2A Phosphatase Activator (PTPA) in the biogenesis of PP2A in mammalian cells

2008
Protein phosphatase 2A (PP2A) is an essential intracellular serine/threonine phosphatase and is a heterotrimer built up by a well-conserved catalytic subunit, a scaffolding subunit and one member out of a family of regulatory subunits, which determines the substrate specificity, (sub) cellular localization and catalytic activity of the PP2A.
openaire   +1 more source

PP2A in the Regulation of Cell Motility and Invasion

Current Protein & Peptide Science, 2011
Cell motility is a very critical phenomenon that plays an important role in the development of eukaryotic organisms. One of the well studied cell motility phenomena is chemotaxis, which is described as a directional movement of cell in response to changes in external chemotactic gradient.
openaire   +2 more sources

Interactions of PP2A inhibitor proteins with PP2A regulatory subunits

2020
Fosfataasit ovat tärkeitä solun sisällä tapahtuvan säätelyn kannalta. Proteiinifosfataasi 2A (PP2A) on yksi näistä säätelijöistä ja sen normaali toiminta liittyy solusyklin aktivointiin. Kun PP2A:n normaalia toimintaa häiritään, voi sen seurauksena ilmetä erilaisia sairauksia, kuten syöpää.
openaire   +1 more source

Review for "Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A"

2021
  +5 more sources

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Cell, 2021
Nathanael Gray, Jarrod J Sandow, Ricky W Johnstone   +2 more
exaly  

I1 PP2A and I2 PP2A

1998
Mei Li, Zahi Damuni
openaire   +1 more source

Selective PP2A Enhancement through Biased Heterotrimer Stabilization

Cell, 2020
Egon Ogris, Matthew D Galsky, Nilesh Zaware   +2 more
exaly  

PP2A in B cells

Nature Immunology, 2018
openaire   +2 more sources