Results 31 to 40 of about 1,152 (97)

Early‐Onset Prostate Cancer: Epidemiology, Risk Factors, Biology, Clinical Features, Management, and Early Detection

MedComm, Volume 7, Issue 8, August 2026.
EOPC is a distinct clinicopathological entity separable from SOPC, differing fundamentally in genetic susceptibility, TMPRSS2:ERG fusion frequency, and survival outcomes. Although research remains nascent, this review provides the first comprehensive synthesis of current evidence, offering a critical foundation to guide future investigations into this ...
Xingyu Xiong, Weizhen Zhu, Weichao Huang, Shiyu Zhang, Qi Deng, Jie Yang, Hang Xu, Qiang Wei, Lu Yang   +8 more
wiley   +1 more source

Addressing Future Changes in Communication Using Hypothetical Scenarios With People With Primary Progressive Aphasia and Care Partners: A Conversation Analytic Study

International Journal of Language &Communication Disorders, Volume 61, Issue 3, May/June 2026.
ABSTRACT Background People with primary progressive aphasia (PPA) will experience a decline in language and cognitive function, and behavioural changes are not uncommon. Decline in everyday skills has been reported and becomes more pronounced over time.
Winsnes Ingvild, Halvorsen Mia, Krogh Elise, Volkmer Anna   +3 more
wiley   +1 more source

Construction and Biological Characterization of Papaya Leaf Curl Guangdong Virus Infectious cDNA Clone

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Viral diseases are important diseases on cash crops such as passion fruit, among which PaLCuGDV is one of the more severe in recent years. We constructed an infectious clone of PaLCuGDV for the first time and confirmed its infectivity through biological assays.
Sheng Xu, Gaoli Wu, Zhaoyao Yu, Chengxi Yang, Xiangru Chen   +4 more
wiley   +1 more source

Characterization of Dynamin-related proteins (DRP) in bread wheat: TaDRP1D-B as regulator of biotic and abiotic stresses

Plant Stress
Bread wheat (Triticum aestivum) is a vital global staple food, providing 30 % of the world's caloric intake and nutritional needs. It was domesticated over 10,000 years ago and adapted to various biotic and abiotic stresses, crucial for maintaining food ...
Zhiwei Wang, Aimen Shafique, Bofeng Yu, Badr Alharthi, Naushad Ali, Muhammad Salman Mubarik, Hafiz Saeed ur Rehman, Rashid Iqbal, Farrukh Azeem, Hongxing Xu   +9 more
doaj   +1 more source

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Drivers of Diagnostic Delay in Mitochondrial Disease: Missed Recognition of Canonical Features

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Diagnostic delay is common in mitochondrial disease, and its drivers remain unclear despite advances in molecular diagnostics. We retrospectively analyzed 61 individuals with molecularly confirmed mitochondrial disease at the Mount Sinai Mitochondrial Disease Clinic, diagnosed after 2016.
Rory J. Tinker, Neil Jacob, Mohammad Ghouse Syed, Janhawi Kelkar, Colleen Donnelly, Ibrahim Elsharkawi, Jaya Ganesh, Bruce D. Gelb, Vikas Pejaver, Tamas Kozicz, Eva Morava   +10 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, Volume 19, Issue 12, Page 3706-3728, December 2025.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances

Pharmaceuticals
In the text, the synthesis and characteristics of the novel ONS-type vanadium (V) complexes with thioanilide derivatives of amino acids are described. They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the ...
Grzegorz Kazek, Monika Głuch-Lutwin, Barbara Mordyl, Elżbieta Menaszek, Monika Kubacka, Anna Jurowska, Dariusz Cież, Bartosz Trzewik, Janusz Szklarzewicz, Monika A. Papież   +9 more
doaj   +1 more source

Tau Axonal Sorting and Interaction With Synaptic Plasticity Modulators Is Domain‐ and Isoform‐Dependent in Human iPSC‐Derived Neurons

Aging Cell, Volume 24, Issue 11, November 2025.
Efficient axonal Tau sorting requires the PRR2 domain but does not depend on AT8 or KXGS phosphorylation, the MT affinity, the C‐terminal repeat domains, or the N‐terminal tail of Tau. Human 0N4R‐Tau shows isoform‐specific interaction with modulators of synaptic plasticity involved in spine function under both normal and AD conditions.
Michael Bell‐Simons, Helen Breuer, Laura Wunderlich, Hanin Chmes, Daniel Adam, Jennifer Klimek, Sarah Buchholz, Hans Zempel   +7 more
wiley   +1 more source

Therapeutic Benefits of Topical Omega‐3 Polyunsaturated Fatty Acids in Skin Diseases and Cosmetics: An Updated Systematic Review

Journal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.
ABSTRACT Background Oral supplementation with omega‐3 polyunsaturated fatty acids (ω‐3 PUFAs) has shown beneficial effects in some dermatologic diseases (i.e., atopic dermatitis, acne, psoriasis, burns), but the actual effect of local application of ω‐3 PUFAs for improving skin health is still under investigation.
Laura Mateu‐Arrom, Ignasi Mora, Leia Garrote   +2 more
wiley   +1 more source