Results 151 to 160 of about 5,261 (261)

Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8+ T cell attack in the CNS gray matter

, 2014
Background: Neural-antigen reactive cytotoxic CD8+ T cells contribute to neuronal dysfunction and degeneration in a variety of inflammatory CNS disorders.
Bittner, S. (Stefan), Bobak, N. (Nicole), Göbel, K. (Kerstin), Herrmann, A.M. (Alexander), Hicking, G. (Gordon), Melzer, N. (Nico), Meuth, S. (Sven), Wiendl, H. (Heinz)   +7 more
core   +1 more source

Biophysical and pharmacological characterisation of recombinant and native rat P2X7 receptors

, 2009
P2X7 receptors exhibit a mainly non-neuronal localisation on immune and glial cells and primarily function as non-selective cation channels. After prolonged or repeated exposure to agonist, functional and cellular changes occur: the formation of a ...
Lappin, Sarah Crawford, Lappin, Sarah Crawford   +1 more
core   +1 more source

Activity-dependent oligodendrocyte calcium dynamics and their changes in Alzheimer's disease. [PDF]

Front Cell Neurosci, 2023
Yoshida K, Kato D, Sugio S, Takeda I, Wake H.   +4 more
europepmc   +1 more source

The gaseous mediator, hydrogen sulphide, inhibits in vitro motor patterns in the human, rat and mouse colon and jejunum

, 2008
Hydrogen sulphide (H2S) has been recently proposed as a transmitter in the brain and peripheral tissues. Its role in the gastrointestinal tract is still unknown despite some data which suggest an involvement mediating smooth muscle relaxation. The aim of
Beyak, M.J., Clavé, P., Donovan, J., Gallego, D., Grundy, D., Jiménez, M., Rahmati, R.   +6 more
core   +1 more source

PPADS and suramin as antagonists at cloned P2Y‐ and P2U‐purinoceptors

British Journal of Pharmacology, 1996
S. Charlton, Colin A. Brown, G. Weisman, J. T. Turner, L. Erb, M. Boarder   +5 more
semanticscholar   +1 more source

PPAD-Membership for Problems with Exact Rational Solutions: A General Approach via Convex Optimization

Proceedings of the 56th Annual ACM Symposium on Theory of Computing
We introduce a general technique for proving membership of search problems with exact rational solutions in PPAD, one of the most well-known classes containing total search problems with polynomial-time verifiable solutions. In particular, we construct a "pseudogate", coined the linear-OPT-gate, which can be used as a "plug-and-play" component in a ...
Aris Filos-Ratsikas, Kristoffer Arnsfelt Hansen, Kasper Høgh, Alexandros Hollender   +3 more
openaire   +3 more sources

Can Almost Everybody be Almost Happy? PCP for PPAD and the Inapproximability of Nash [PDF]

, 2015
Yakov Babichenko, Christos H. Papadimitriou, Aviad Rubinstein   +2 more
openalex   +1 more source

Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome. [PDF]

Front Immunol, 2023
Kargarpour Z, Cicko S, Köhler TC, Zech A, Stoshikj S, Bal C, Renner A, Idzko M, El-Gazzar A.   +8 more
europepmc   +1 more source

Vasoconstrictor and vasodilator responses to various agonists in the rat perfused mesenteric arterial bed: selective inhibition by PPADS of contractions mediated via P2x‐purinoceptors

British Journal of Pharmacology, 1994
U. Windscheif, V. Ralevic, H. Bäumert, E. Mutschler, G. Lambrecht, G. Burnstock   +5 more
semanticscholar   +1 more source

Antidepressant-like effects of P2 purinergic antagonist PPADS is dependent on serotonergic and noradrenergic integrity [PDF]

, 2016
Cassiano R.A.F. Diniz, Murilo Wendeborn Rodrigues, Plínio Casarotto, Vitor Silva Pereira, Carlos C. Crestani, Sâmia Joca   +5 more
openalex   +1 more source