Results 101 to 110 of about 33,868 (177)
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández +4 more
wiley +1 more source
Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir +3 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li +10 more
wiley +1 more source
eFood, Volume 7, Issue 3, June 2026.Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
PPARα: Linking Cardiac Metabolism to Therapeutic Opportunities in Cardiovascular Diseases. [PDF]
CellsRoes M, Libert C, Vandewalle J.
europepmc +1 more source
Nutritional, phytochemical, and potential health benefits of Monostroma spp.: A systematic review
Food Biomacromolecules, Volume 3, Issue 2, Page 252-272, June 2026.Abstract Monostroma spp., belonging to the green seaweed, has been known to be health‐promoting food items as prophylactic agents worldwide. It has shown wide arrays of bioactivities for the prevention and treatment of various diseases. A total of 47 articles were selected to review following the Preferred Reporting Items for Systematic reviews and ...
Md Shariful Islam
wiley +1 more source
Calculus Bovis ameliorates primary sclerosing cholangitis via a dual-pronged mechanism restoring bile acid and lipid homeostasis in the gut-liver axis. [PDF]
Chin MedGong X +8 more
europepmc +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Dietary microalgae oil might reverse hepatic lipid deposition in a mouse model of fatty liver. This intervention significantly improves the overall fatty liver condition by reducing lipid accumulation and simultaneously restoring insulin sensitivity. ABSTRACT Non‐alcoholic fatty liver disease (NAFLD) is a leading cause of liver‐related mortality and ...
Athba AlQahtani +8 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 6, June 2026.Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu +7 more
wiley +1 more source
Cholesterol Overload Drives Hepatic Steatosis by Inhibiting OGT-dependent PPARα O-GlcNAcylation and Transactivation. [PDF]
Int J Biol SciGuo R +8 more
europepmc +1 more source