Results 111 to 120 of about 33,868 (177)

Effects and Mechanisms of Stevioside on Metabolic Dysfunction‐Associated Steatotic Liver Disease

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
SV has the potential to prevent or treat MASLD by improving hepatic lipid metabolism, enhancing anti‐inflammatory and antioxidant capacity, and attenuating hepatic fibrosis. ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects more than 30% of adults globally and has emerged as a significant public health concern ...
Kangjun Li, Changfa Zhang, Lili Kang, Yunping Mu, Zemin Li, Jingyi Zhang, Guowei Li   +6 more
wiley   +1 more source

Fenofibrate alleviates the brain edema after traumatic brain injury by enhancing endothelial OXPHOS. [PDF]

Redox Biol
Feng Q, Gao Y, Gu X, Zhao X, Liu X, Ma Z, Qi W, He Z, Han Y, Zhang J, Wang W, Li Z, Zhang D, Huang J, Lin Y, Hui J, Onondari B, Erdenetsetseg G, Mao Q, Jiang J, Zhou Y, Weng W, Zhang Y, Feng J.   +23 more
europepmc   +1 more source

Virgin Coconut Oil Attenuates Diabetic Kidney Disease via Gut Microbiota‐Metabolism‐Inflammation Axis Modulation in Type 2 Diabetic Mice

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study elucidates the multi‐targeted mechanisms of Virgin Coconut Oil (CO) as a dietary intervention for ameliorating Diabetic Kidney Disease (DKD). High‐purity medium‐chain fatty acids (MCFAs, primarily octanoic acid [C8:0] and decanoic acid [C10:0]) in CO significantly remodel the gut microbiota by enriching short‐chain fatty acid (SCFA ...
Keke Shao, Yun Cao, Ruiqi Gao, Xueyun Dong, Xuehui Liu, Hao Xu, Yunhan Xie, Linlin Xu, Jiayuan He, Min Chen, Leilei Zhang, Asmaa Ali, Liang Wu, Pingping Wang   +13 more
wiley   +1 more source

CircRPPH1 promotes hepatocellular carcinoma progression through inhibiting PPARα transcription and accelerating its ubiquitination and degradation. [PDF]

Cell Mol Life Sci
Ru W, Lu Y, Gan L, Yao S, Wan H, Nie F, Di S, Guo Y, Huang Q, Yin S, Ning J, Yang F, Qin W, Wen W.   +13 more
europepmc   +1 more source

Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture

Advanced Genetics, Volume 7, Issue 2, June 2026.
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
wiley   +1 more source

Integrating Network Pharmacology and Experimental Validation of Oleanolic Acid Targeting the PPARα-CPT1A Axis to Modulate Lipid Metabolism in Hepatocellular Carcinoma Cells. [PDF]

Int J Mol Sci
Liu Y, Zhang D, Liu D, Wang M, Lyu H, Sun Y.   +5 more
europepmc   +1 more source

PPARα deficiency causes skin dysbiosis and triggers innate immunity in keratinocytes. [PDF]

Cell Death Dis
Blunder S, Minzaghi D, Pavel P, Berktold M, Hermann M, Ploner C, Schöpf C, Marx F, Dubrac S.   +8 more
europepmc   +1 more source

Dandruff Is a Low‐Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin‐17‐Producing T Cells, and N‐Acyl Ethanolamines

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Background Dandruff features epidermal scaling but lacks overt signs of inflammation, such as erythema. Characterisation of its inflammatory profile may improve understanding of the underlying inflammatory mechanisms and therefore indicate alternative approaches for treatment.
Alexandra C. Kendall, Karishma Mohamed, Holly Linley, Marta M. Koszyczarek, Anne Chandidzura, Christopher E. M. Griffiths, Tracy Hussell, Amy E. Saunders, Anna Nicolaou   +8 more
wiley   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα. [PDF]

Environ Health Perspect
Zhang G, Zhao L, Wang J, Wang K, Ji X, Hu R, Hou T, Zhang L, Li R, Sun Q, Zhang K, Liu C.   +11 more
europepmc   +1 more source