Senescence in hepatic stellate cells as a mechanism of liver fibrosis reversal: a putative synergy between retinoic acid and PPAR-gamma signalings [PDF]
, 2016 Hepatic stellate cells (HSCs), also known as perisinusoidal cells, are pericytes found in the perisinusoidal space of the liver. HSCs are the major cell type involved in liver fibrosis, which is the formation of scar tissue in response to liver damage ...
Oben, JA +3 more
core
Acetylation-defective mutant of Pparγ is associated with decreased lipid synthesis in breast cancer cells. [PDF]
, 2014 In our prior publications we characterized a conserved acetylation motif (K(R)xxKK) of evolutionarily related nuclear receptors. Recent reports showed that peroxisome proliferator activated receptor gamma (PPARγ) deacetylation by SIRT1 is involved in ...
Addya, Sankar +12 more
core +1 more source
过氧化物酶增生物-激活受体γ2基因多态性与2型糖尿病的相关性
Zhongguo shiyan zhenduanxue, 2010 目的探讨PPARγ2基因多态性与2型糖尿病的关系。方法以rs1875796为遗传标记,应用多聚酶链-限制性片段长度多态性（PCR-RFLP）技术检测250例2型糖尿病患者和337例健康对照人群PPARγ2基因型。结果 Rs1875796基因型频率CC:CT:TT在2型糖尿病和正常对照组的频率分布分别为2.8%:27.2%:70.0%和2.7%:25.5%:71.8%;C等位基因和T等位基因在2型糖尿病组和正常对照组的频率分布分别为16.4%:83.6%和15.4%:84.6%,两组间的等位基因 ...
高鹏, 吴江, 杜丹华, 张颖
doaj
Control of adipogenesis by fatty acids [PDF]
A obesidade é um dos principais problemas de saúde pública. Indivíduos obesos são mais suscetíveis a desenvolver doenças cardiovasculares e diabetes melito tipo 2. A obesidade resulta do aumento no tamanho e no número de adipócitos.
ALONSO-VALE, Maria Isabel Cardoso +3 more
core +1 more source
New molecular approaches in adipogenesis regulation: The connexin 43 role [PDF]
, 2016 Indexación: Scopus; Redalyc.La prevalencia de la obesidad a nivel mundial se ha incrementado rápidamente durante los últimos años debido principalmente a los cambios en el estilo de vida de la población con un aumento significativo en el consumo de ...
Cerda, M. +13 more
core
Intranuclear localization of EGFP-mouse PPARγ1 in bovine fibroblast cells [PDF]
, 2010 Objective: The aim of this study was to clone PPARγ1 cDNA in an appropriate mammalian expression vector, with a chimeric cDNA form, encompassing PPARγ with enhanced green fluorescent protein (EGFP) cDNA.
Baharvand, Hossein. +7 more
core +1 more source
Ciglitazone-a human PPARγ agonist-disrupts dorsoventral patterning in zebrafish. [PDF]
, 2019 Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that regulates lipid/glucose homeostasis and adipocyte differentiation.
Cheng, Vanessa +3 more
core
Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes [PDF]
, 2007 Hassan Afif +6 more
core +1 more source
Comparative Analysis of Osteogenic/Chondrogenic Differentiation Potential in Primary Limb Bud-Derived and C3H10T1/2 Cell Line-Based Mouse Micromass Cultures [PDF]
, 2020 Juhász, Tamás +4 more
core +1 more source
EVA1A Regulates Hepatic Lipid Homeostasis by Modulating CD36 Expression and Its Palmitoylation. [PDF]
Research (Wash D C)Yang D +13 more
europepmc +1 more source