Results 81 to 90 of about 6,404 (164)

PPARγ Agonistic Activity of Mimulone and Diplacone Encapsulated in Liposomes and Cyclodextrin Complexes

ChemistryOpen, Volume 14, Issue 12, December 2025.
Encapsulation of the geranylated flavanones mimulone and diplacone in hydroxypropyl‐β‐cyclodextrins (HP‐β‐CDs) and liposomes is evaluated for their peroxisome proliferator‐activated receptor gamma agonistic activity. While liposomes reduce efficacy, HP‐β‐CDs preserve up to 91.5% of mimulone's activity and mitigate diplacone's cytotoxicity, highlighting
Daniela Nykodýmová, Lenka Molčanová, Jan Kotouček, Josef Mašek, Jakub Treml   +4 more
wiley   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Adipocyte‐specific ablation of plakoglobin in mice does not affect adiposity but results in sexual‐dimorphic effects on weight gain

Physiological Reports, Volume 13, Issue 24, December 2025.
Abstract The main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β‐catenin homolog, plakoglobin, in the regulation of ...
Frederic Abou Azar, Alexis Vivoli, Arturo I. Machuca‐Parra, Frédéric Paré, Mete Civelek, Weinian Shou, Gareth E. Lim   +6 more
wiley   +1 more source

Naringin Stimulates Osteogenic Differentiation of Rat Bone Marrow Stromal Cells via Activation of the Notch Signaling Pathway

Stem Cells International, 2016
Naringin is a major flavonoid found in grapefruit and is an active compound extracted from the Chinese herbal medicine Rhizoma Drynariae. Naringin is a potent stimulator of osteogenic differentiation and has potential application in preventing bone loss.
Guo-yong Yu, Gui-zhou Zheng, Bo Chang, Qin-xiao Hu, Fei-xiang Lin, De-zhong Liu, Chu-cheng Wu, Shi-xin Du, Xue-dong Li   +8 more
doaj   +1 more source

Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2

Liver Research, 2018
Peroxisome proliferator-activated receptor gamma (PPARγ or PPARG) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. It plays a master role in the differentiation and proliferation of adipose tissues. It has
Yoon Kwang Lee, Jung Eun Park, Mikang Lee, James P. Hardwick   +3 more
doaj   +1 more source

Вклад молекулярно-генетических маркеров в развитие синдрома поликистозных яичников [PDF]

, 2015
ПОЛИКИСТОЗНОГО ЯИЧНИКА СИНДРОМ /генетПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙГЕНЕТИЧЕСКИЕ ...
ружило, О. С.
core  

TonEBP/NFAT5 promotes obesity and insulin resistance by epigenetic suppression of white adipose tissue beiging [PDF]

, 2019
Tonicity-responsive enhancer binding protein (TonEBP or NFAT5) is a regulator of cellular adaptation to hypertonicity, macrophage activation and T-cell development. Here we report that TonEBP is an epigenetic regulator of thermogenesis and obesity.
AM Cypess, AY Kim, C Deng, C Küper, C Lopez-Rodriguez, C Postic, DP Bartel, E Kiskinis, EP Mottillo, F Hu, GS Hotamisligil, H Miyakawa, H Xie, HH Lee, HJ Yoon, I Serr, J Espada, J Symmank, J Wu, JA Dolan, JA Halterman, JH Lee, JR Arch, Jun Ho Lee, K Hotta, K Inokuma, M Buxadé, M Harms, M Kleinewietfeld, M Rosenbaum, M Uldry, MA Van Baak, N Ouchi, NR Rose, O Zierau, P Cohen, P Trayhurn, RG Baker, RT Jung, S Choi, S Schenk, SD Lee, SJ Kim, SY Choi, SY Choi, T Yoshida, TM Larsen, WY Go, X Wang   +48 more
core   +1 more source

Influence of the unsaturated fatty acids on body weight, glucose, and lipids metabolism in obese women with Pro12Pro genotype in PPARγ2 gene

Nutrición Hospitalaria
Background: The type of dietary fatty acid may have different effects on obesity and its complications, however, these effects can be influenced by genes and polymorphisms, such as peroxisome proliferator-activated receptor γ isoform 2 (PPARγ2). Moreover,
Márcia Fófano do Lago, Vanessa Chaia Kaippert, Débora Lopes Souto, Eliane Lopes Rosado   +3 more
doaj   +1 more source

Wnt inhibitor XAV-939 promote the adipogenic differentiation of dental pulp stem cells

口腔疾病防治, 2016
Objective To evaluate the effect of Wnt inhibitor XAV-939 on the proliferation and adipogenic differentiation of dental pulp stem cells (DPSCs).Methods The effect of XAV-939 on the proliferation of DPSCs was analyzed by cell counting kit-8(CCK-8).
WEN Jun, XU Shuai-mei, LIU Ying
doaj   +1 more source

Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

Molecular Metabolism, 2017
Objective: Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro. Recent advances in gene-editing
Morten Lundh, Kaja Pluciñska, Marie S. Isidor, Patricia S.S. Petersen, Brice Emanuelli   +4 more
doaj   +1 more source