Results 71 to 80 of about 6,404 (164)
Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice. [PDF]
PLoS ONE, 2016 Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and glucose homeostasis.
Peter E O'Donnell +6 more
doaj +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.ABSTRACT Background High‐intensity interval training (HIIT) with or without L‐citrulline (CIT) oral supplementation improves body composition, functional capacities and muscle health in obese older adults, potentially through microRNA‐driven regulation.
Alexandre Mercier‐Guery +13 more
wiley +1 more source
STIM2?? is upregulated by insulin signaling and involved in adipogenesis [PDF]
, 2015 Department of Biological SciencesCalcium ion play an important role in lipid formation and adipogenesis. The STIM1 and STIM2 are endoplasmic reticulum Ca2+ sensors which activate and regulate Orai, store operated calcium channel. I am interested in stim2?
Kim, Mi Ri
core
The Mechanistic Role of PPARγ in Wound Healing
PPAR Research, Volume 2026, Issue 1, 2026.The receptor known as peroxisome proliferator‐activated receptor gamma (PPARγ) is crucial for effective wound healing, and recent progress has given a deeper understanding of its complex functions. As a biological switch, PPARγ regulates the immune response by shifting macrophages from promoting inflammation to supporting tissue regeneration, while ...
Zhaojun Wang +6 more
wiley +1 more source
Structure and function research of the nuclear receptor PPARγ and its novel selective regulator [PDF]
, 2016 过氧化物酶体增殖剂激活受体家族(PPARs)是一类配体依赖型的激活因子，它们是核受体超家族中的重要成员。PPARs是机体调节新陈代谢平衡的关键转录因子，因此PPARs也成为了研发治疗糖尿病，心血管疾病等代谢相关疾病药物的热门分子靶标。 糖尿病是困扰现代人健康的一组常见代谢性疾病，但是目前临床上仍然缺乏安全且有效的糖尿病治疗药物。噻唑烷二酮（Thiazolidinedione，TZD)类药物是经典的PPARγ完全激动剂，由于它能够改善由糖尿病引起的胰岛素耐受等症状，目前已经运用于临床治疗Ⅱ型糖尿病 ...
邱琳
core
Infectious SIV resides in adipose tissue and induces metabolic defects in chronically infected rhesus macaques [PDF]
, 2016 Additional file 1. General method for isolation of stromal-vascular-fraction (AT-SVF) cells from adipose tissue of rhesus macaques, and subsequent analyses.
Ashok Balasubramanyam +7 more
core +7 more sources
Advanced Science, Volume 12, Issue 48, December 29, 2025.The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song +11 more
wiley +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li +8 more
wiley +1 more source
Growth factor liberation and DPSCs response following dentine conditioning [PDF]
, 2016 Liberation of the sequestrated bioactive molecules from dentine by the action of applied dental materials has been proposed as an important mechanism in inducing a dentinogenic response in teeth with viable pulps.
Gleeson, Hannah +5 more
core +1 more source
Interaction of genetic risk factors confers increased risk for metabolic syndrome: the role of peroxisome proliferator-activated receptor γ [PDF]
, 2014 AIM: The aim of the study was to estimate the influence of interactions between peroxisome proliferator-activated receptor γ (PPARγ) and target genes lipoprotein lipase (LPL), interleukin 6 (IL6), angiotensin converting enzyme (ACE), and angiotensin ...
Božina, Tamara +5 more
core +1 more source