Results 51 to 60 of about 6,404 (164)

A novel 3T3-L1 preadipocyte variant that expresses PPARγ2 and RXRα but does not undergo differentiation

Journal of Lipid Research, 1998
This report describes a novel adipocyte-like cell line termed 3T3-L1/RB1 that was derived from preadipocyte cell line, 3T3-L1. The 3T3-L1/RB1 cells continued to divide after reaching confluence, formed foci, and constitutively expressed a low level of ...
Rebecca A. Baillie, Xiaoming Sha, Philippe Thuillier, Steven D. Clarke   +3 more
doaj   +1 more source

Polymorphism of Pro12Ala in the peroxisome proliferator-activated receptor 2 gene in Iranian diabetic and obese subjects

, 2009
Background: Peroxisome proliferator-activated receptor 2 (PPAR2) is a nuclear receptor that regulates adipocyte differentiation, lipid metabolism, and insulin sensitivity.
Akrami, S.M., Amiri, P., Doosti, M., Golmohammadi, T., Heshmat, R., Mirzaei, H., Nakhjavani, M.   +6 more
core   +1 more source

PPARγ2 Pro12Ala Polymorphism is Associated in Children With Traits Related to Susceptibility to Type 2 Diabetes

Frontiers in Pharmacology, 2021
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear receptor that regulates glucose and lipid metabolism. Pharmacological activators of PPARγ are being used as a treatment of obesity related disorders such as ...
Claudia Vales-Villamarín, Olaya de Dios, Iris Pérez-Nadador, Teresa Gavela-Pérez, Leandro Soriano-Guillén, Carmen Garcés   +5 more
doaj   +1 more source

Hyperglycemia Leads to BMSC Impaired Osteogenesis, Enhanced Adipogenesis, and Altered Metabolism

Journal of Cellular Biochemistry, Volume 127, Issue 4, April 2026.
ABSTRACT Diabetes is a major risk factor for osteoporosis, which negatively impacts bone health, but the mechanisms underlying the effects of hyperglycemia on bone marrow mesenchymal/stromal cells (BMSC) are not fully understood. This study investigated how high glucose levels influence BMSC differentiation, proliferation, viability, and metabolism ...
Suzanna Shirazi, Ezaldeen Esawi, Zeyad D. Nassar, Stan Gronthos, Dimitrios Cakouros   +4 more
wiley   +1 more source

Immunoreactivities of PPARγ2, leptin and leptin receptor in oviduct of Chinese brown frog during breeding period and pre-hibernation

European Journal of Histochemistry, 2014
The Chinese brown frog (Rana dybowskii) is a special amphibian with one unique physiological phenomenon, which is that its oviduct expands prior to hibernation, instead of during the breeding period.
Y. Liu, J. Weng, S. Huang, Y. Shen, X. Sheng, Y. Han, M. Xu, Q. Weng   +7 more
doaj   +1 more source

Maternal Obesity Programs Adipogenic Commitment in Neonatal Mesenchymal Stem Cells: A Link to Redox‐Dependent FOXO1 Signaling

Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.
ABSTRACT Maternal obesity increases the risk of obesity and metabolic disease in the offspring, yet the cellular mechanisms that program adipose tissue development remain poorly understood. Mesenchymal stem cells (MSCs), the precursors of adipocytes, may represent an early target of metabolic programming during fetal development.
Sofía Bellalta, Erika Pinheiro‐Machado, Theo Borghuis, Jelmer Prins, Torsten Plösch, Paola Casanello, Marijke Faas   +6 more
wiley   +1 more source

A mutation detection in a transcription factor for adipocyte development in children with severe obesity [PDF]

, 2008
Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenObjective: A substantial proportion of human obesity may be explained by genetic variability.
Gunnlaug Hjaltadóttir, Hákon Hákonarson, Tómas Þór Ágústsson, Árni V. Þórsson, Ísleifur Ólafsson   +4 more
core  

Differential expression of CCN-family members in primary human bone marrow-derived mesenchymal stem cells during osteogenic, chondrogenic and adipogenic differentiation [PDF]

, 2005
Background The human cysteine rich protein 61 (CYR61, CCN1) as well as the other members of the CCN family of genes play important roles in cellular processes such as proliferation, adhesion, migration and survival.
Hendrich Christian, Schneidereit Jutta, Noth Ulrich, Schutze Norbert, Jakob Franz   +4 more
core   +2 more sources

Physiological significance of autocrine orexinergic signaling in extra‐hypothalamic tissues

Physiological Reports, Volume 14, Issue 8, April 2026.
Mechanisms of autocrine orexinergic effects in extra‐hypothalamic tissues. Abstract Orexin‐A and orexin‐B, originally discovered as hypothalamic neuropeptides, have been detected in extra‐hypothalamic tissues together with their receptors (OX1R and OX2R) since the early 2000s.
Jean Claude Hakizimana, Makinde Vincent Olubiyi, Abdullateef Isiaka Alagbonsi   +2 more
wiley   +1 more source

Identification of major dioxin-like compounds and androgen receptor antagonist in acid-treated tissue extracts of high trophic-level animals [PDF]

, 2011
We evaluated the applicability of combining in vitro bioassays with instrument analyses to identify potential endocrine disrupting pollutants in sulfuric acid-treated extracts of liver and/or blubber of high trophic-level animals.
Abraham Brouwer, Bart van der Burg, Behnisch P. A., Brack W., Brack W., Burgess R. M., Chou P. H., Go Suzuki, Hamers T., Hamers T., Hanari N., Hidetaka Takigami, Houtman C. J., Howard G. J., Imaeda D., Isobe T., Kajiwara N., Kelce W. R., Kojima H., Kojima H., Kubota A., Kunisue T., Kunisue T., Li Y. F., Marja Lamoree, Martin van Velzen, Masayuki Someya, Masunaga S., Nakata H., Nguyen M. Tue, Noma Y., Nomiyama K., Park J. S., Qu G. B., Ren M., Sakai S., Sander van der Linden, Schroijen C., Shin Takahashi, Shinsuke Tanabe, Sonneveld E., Sonneveld E., Suzuki G., Suzuki G., Suzuki G., Tadasu K. Yamada, Tanabe S., Thomas K. V., Tomohiko Isobe, Tue N. M., van den Berg M., van der Burg B., van der Burg B., van der Burg B., van der Linden S. C., Weiss J. M., Yuko Tajima   +56 more
core   +2 more sources