Results 41 to 50 of about 6,404 (164)

Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study

BMC Gastroenterology, 2010
Background Peroxisome proliferator-activated receptors (PPARs) play key roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Aim to assess the effect of functional single nucleotide polymorphisms (SNPs) of PPARα and PPARγ2, previously ...
Dongiovanni Paola, Rametta Raffaela, Fracanzani Anna, Benedan Luca, Borroni Vittorio, Maggioni Paolo, Maggioni Marco, Fargion Silvia, Valenti Luca   +8 more
doaj   +1 more source

SENP3-Mediated PPARγ2 DeSUMOylation in BM-MSCs Potentiates Glucocorticoid-Induced Osteoporosis by Promoting Adipogenesis and Weakening Osteogenesis

Frontiers in Cell and Developmental Biology, 2021
Glucocorticoid-induced osteoporosis (GIOP) is the most common secondary osteoporosis and reduced bone formation was the main pathological change in GIOP.
Yongxing Zhang, Yongxing Zhang, Yongxing Zhang, Yang Chen, Hangxiang Sun, Hangxiang Sun, Wenkan Zhang, Wenkan Zhang, Lingling Zhang, Lingling Zhang, Hengyuan Li, Hengyuan Li, Xin Huang, Xin Huang, Jie Yang, Zhaoming Ye, Zhaoming Ye   +16 more
doaj   +1 more source

The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner. [PDF]

PLoS ONE, 2014
Differentiation signaling results in reprogramming of cellular gene expression that leads to morphological changes and functional specialization of a precursor cell.
Scott E LeBlanc, Qiong Wu, A Rasim Barutcu, Hengyi Xiao, Yasuyuki Ohkawa, Anthony N Imbalzano   +5 more
doaj   +1 more source

Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
HFD withdrawal results in early restoration of systemic glucose tolerance and PVAT lipid unsaturation that is temporarily dissociated from the reversal of endothelial dysfunction in aorta that may be linked to altered PVAT function featured by impaired guanylate cyclase signaling pathway.
Krzysztof Czamara, Izabela Czyzynska‐Cichon, Anna Bar, Ewa Stanek, Mateusz Wawro, Marta Z. Pacia, Zeinep Berkimbayeva, Brygida Marczyk, Elvira Bragado‐García, Paloma Palma‐Guzman, Maria S. Fernandez‐Alfonso, Stefan Chlopicki   +11 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, Volume 16, Issue 5, Page 932-943, May 2026.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Lipid-laden multilocular cells in the aging thymus are phenotypically heterogeneous [PDF]

, 2015
Intrathymic lipid-laden multilocular cells (LLMC) are known to express pro-inflammatory factors that might regulate functional activity of the thymus. However, the phenotype of ageassociated intrathymic LLMC is still controversial.
Andrade, L.R. (Leonardo), Borojevic, R. (Radovan), De Mello Coelho, V. (Valeria), Ewijk, W. (Willem) van, Langhi, L.G.P. (Larissa G. P.), Shimabukuro, M.K. (Marilia Kimie), Taub, D.D. (Dennis D.)   +6 more
core   +4 more sources

Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma 2 may be associated with adverse neurodevelopment in European preterm babies

Brain and Behavior, 2021
Introduction Prematurity is the leading cause of death and disability in children under 5 years of age. Understanding the molecular mechanisms of the biological processes involved in preterm brain injury may help develop novel neuroprotective treatment ...
Suresh Victor, Andrew Chew, Shona Falconer   +2 more
doaj   +1 more source

Pathophysiology and Molecular Signalling in Osteoporosis: Linking Risk Factors to Bone Loss

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Osteoporosis is a prevalent skeletal disorder characterised by progressive reduction in bone mass, microarchitectural deterioration, and increased fracture susceptibility. In India, approximately one‐third of the elderly population is affected by bone‐related disorders, and the global burden of osteoporosis continues to rise.
Pramoda G., Kamini Shivhare, Piyush Kumar Gupta, Amirhossein Sahebkar, Prashant Kesharwani, Rahul Shukla   +5 more
wiley   +1 more source

Rapid in vivo PGC-1 mRNA upregulation in brown adipose tissue of Wistar rats by a beta(3)-adrenergic agonist and lack of effect of leptin. [PDF]

, 2001
Peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) is highly expressed in brown adipose tissue (BAT) and plays an important role in adaptive thermogenesis.
Frühbeck, G. (Gema), Gomez-Ambrosi, J. (Javier), Martinez, J.A. (José Alfredo)   +2 more
core  

Impact of the Pro12Ala Polymorphism of the PPAR-Gamma 2 Gene on Metabolic and Clinical Characteristics in the Palestinian Type 2 Diabetic Patients

PPAR Research, 2009
Peroxisome proliferators activated receptor-gamma2 (PPARγ2) represents the transcriptional master regulator of adipocyte differentiation and therefore has been suggested as a candidate gene for obesity, insulin resistance, and dyslipidemia. The objective
S. Ereqat, A. Nasereddin, K. Azmi, Z. Abdeen, R. Amin   +4 more
doaj   +1 more source