Results 31 to 40 of about 6,404 (164)

Influence of the body mass and visceral adiposity on glucose metabolism in obese women with Pro12Pro genotype in PPARgamma2 gene. [PDF]

, 2016
Introduction: Glucose metabolism may be altered in obesity and genotype for PPAR 2 can influence this variable. Objective: To evaluate the influence of body mass (BM) and visceral adiposity (VA) in glucose metabolism in morbid obese women with Pro12Pro ...
D'ANDREA, C. L., KAIPPERT, V. C., LAGO, M. F. do, LOPES, M. C. O. dos S., NOGUEIRA, J., OLIVEIRA, E. M. M., ROSADO, E. L., UEHARA, S. K.   +7 more
core   +1 more source

Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes

Frontiers in Pharmacology, 2021
The clinical controversy of rosiglitazone as a hypoglycemic agent is potentially associated with heart failure, mainly due to its potent activation of peroxisome proliferator-activated receptor γ (PPARγ).
Xuemei Cao, Xuemei Cao, Min Mao, Min Mao, Junlin Diao, Junlin Diao, Yi Hou, Yi Hou, Hong Su, Hong Su, Yongjun Gan, Jibin Li, Xiaoyong Tong, Chaodong Wu, Zhong Zuo, Xiaoqiu Xiao, Xiaoqiu Xiao   +16 more
doaj   +1 more source

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function. [PDF]

, 2014
Adipose tissue dysfunction is an important determinant of obesity-associated, lipid-induced metabolic complications. Ceramides are well-known mediators of lipid-induced insulin resistance in peripheral organs such as muscle.
Barbarroja, Nuria, Camargo, Antonio, Cuadrado, Irene, Lopez-Pedrera, Chary, Medina-Gomez, Gema, Nygren, Heli, Oresic, Matej, Pellegrinelli, Vanessa, Pirraco, Ana, Relat, Joana, Rodriguez-Cuenca, Sergio, Summers, Scott A, Symons, J David, Tinahones, Francisco J, Vidal-Puig, Antonio   +14 more
core   +2 more sources

Peroxisome Proliferator-Activated Receptor γ 2 Modulates Late-Pregnancy Homeostatic Metabolic Adaptations

Molecular Medicine, 2016
Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological metabolic adaptation that serves to support ...
Yurena Vivas, Monica Díez-Hochleitner, Adriana Izquierdo-Lahuerta, Patricia Corrales, Daniel Horrillo, Ismael Velasco, Cristina Martínez-García, Mark Campbell, Julio Sevillano, Mercedes Ricote, Manuel Ros, Maria Pilar Ramos, Gema Medina-Gomez   +12 more
doaj   +1 more source

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat. [PDF]

PLoS ONE, 2013
The liver plays a central role in regulating lipid metabolism and facilitates efficient lipid utilization and storage. We discovered that a modest increase in maternal dietary fat in mice programs triglyceride storage in the liver of their developing ...
Xu Xu, Jingjie Hu, Barbara C McGrath, Douglas R Cavener   +3 more
doaj   +1 more source

PPAR gamma Pro(12)Ala polymorphism and risk of acute coronary syndrome in a prospective study of Danes [PDF]

, 2009
Background: Acute coronary syndrome (ACS) is a major cause of morbidity and mortality in the western world. Peroxisome proliferator-activated receptor gamma (PPAR gamma) plays a key role in the regulation of the energy balance, adipocyte differentiation ...
Ulla Vogel, Stine Segel, Claus Dethlefsen, Anne Tjønneland, Anne Thoustrup Saber, Håkan Wallin, Majken K Jensen, Erik B Schmidt, Paal Skytt Andersen, Kim Overvad, S Heikkinen, A Meirhaeghe, M Stumvoll, J Masugi, SS Deeb, A Tonjes, D Altshuler, AS Doney, PM Ridker, T Pischon, L Li, SM Brand-Herrmann, A Tjonneland, AM Joensen, MK Jensen, SA Miller, U Vogel, JD Kalbfleisch, U Vogel, MH Zafarmand, A Doney, AS Doney, U Vogel, MM Swarbrick, J Zhang, I Tegeder, U Vogel   +36 more
core   +5 more sources

Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.

PLoS ONE, 2012
Mice lacking Peroxisome Proliferator-Activated Receptor γ2 (PPARγ2) have unexpectedly normal glucose tolerance and mild insulin resistance. Mice lacking PPARγ2 were found to have elevated levels of Lipocalin prostaglandin D synthase (L-PGDS) expression ...
Sam Virtue, Mojgan Masoodi, Vidya Velagapudi, Chong Yew Tan, Martin Dale, Tapani Suorti, Marc Slawik, Margaret Blount, Keith Burling, Mark Campbell, Naomi Eguchi, Gema Medina-Gomez, Jaswinder K Sethi, Matej Orešič, Yoshihiro Urade, Julian L Griffin, Antonio Vidal-Puig   +16 more
doaj   +1 more source

Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism through PPARγ2 Downregulation. [PDF]

PLoS ONE, 2017
Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis.
Chung-Hwa Park, Jung-Hee Kim, Eun Byul Lee, Wonhee Hur, Oh-Joo Kwon, Hyoung-Jin Park, Seung Kew Yoon   +6 more
doaj   +1 more source

Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter

Genes and Diseases, 2022
The retinoblastoma gene product (pRb) is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific differentiation.
Mikhail Baryshev, Nikolai Petrov, Vladimir Ryabov, Boris Popov   +3 more
doaj   +1 more source

Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]

, 2012
Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie, Forkmann, Thomas, Gläsmer, Heide, Margraf, Jürgen, Teismann, Tobias   +4 more
core   +1 more source