Caspase-6 Controls Lipid and Energy Metabolism in Diet-Induced Obesity. [PDF]
Adv Sci (Weinh)This study reveals an unknown metabolic role of caspase‐6 beyond cell death. Caspase‐6 deficiency protects against HFD‐induced obesity by increasing energy expenditure, reducing inflammation, and improving glucose metabolism. Mechanistically, caspase‐6 cleaves PPARγ and SP1 to suppress ATGL expression.
Gupta A +7 more
europepmc +2 more sources
The Furan Fatty Acids 11M5 and 11D5 Can Act as Activators of Human Peroxisome Proliferator-Activated Receptor Gamma. [PDF]
Mol Nutr Food ResFuran fatty acids are abundant in food such as fatty fish. Here we show that some of these can bind to and act as activators of the nuclear receptors, peroxisome proliferator‐activated receptor gamma (PPAR‐gamma) and retinoid X receptor (RXR), in human cells.
Pospiech J +5 more
europepmc +2 more sources
PPAR Research, 2022 Background. Peroxisome proliferator-activated receptor-γ (PPARγ) gene is located at 3p25 position. PPARγ functions as the master regulator of glucose homeostasis and lipoprotein metabolism, and recent studies have reported that it is involved in various ...
Somayye Taghvaei, Leila Saremi
doaj +1 more source
Cytosolic and nuclear distribution of PPARγ2 in differentiating 3T3-L1 preadipocytes
Journal of Lipid Research, 1998 In light of the pivotal role that PPARγ2 plays in the expression of fat specific genes (e.g., A-FABP), we have examined the hypothesis that a rise in PPARγ2 protein is required for the expression of A-FABP, and that the acceleration of fat cell ...
Philippe Thuillier +3 more
doaj +1 more source
Genetics and Clinical Characteristics of PPARγ Variant-Induced Diabetes in a Chinese Han Population
Frontiers in Endocrinology, 2021 ObjectivesPPARγ variants cause lipodystrophy, insulin resistance, and diabetes. This study aimed to determine the relationship between PPARγ genotypes and phenotypes and to explore the pathogenesis of diabetes beyond this relationship.MethodsPPARγ2 exons
Siqian Gong +17 more
doaj +1 more source
Journal of Diabetes Investigation, 2020 Aims/Introduction Safflower yellow (SY) and its main component, hydroxysafflor yellow A, have been demonstrated to show anti‐obesity effects. Peroxisome proliferator‐activated receptor‐γ2 (PPARγ2) is a critical transcription factor in adipose tissue ...
Kemin Yan +9 more
doaj +1 more source
The PPARγ2 P12A polymorphism is not associated with all-cause mortality in patients with type 2 diabetes mellitus [PDF]
, 2016 The high mortality risk of patients with type 2 diabetes mellitus may well be explained by the several comorbidities and/or complications. Also the intrinsic genetic component predisposing to diabetes might have a role in shaping the risk of diabetes ...
Alberico, Federica +13 more
core +1 more source
The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes [PDF]
, 2015 Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2).
BRUZZESE, DARIO +7 more
core +1 more source
Comparison of three aerobic exercise methods with different intensities on PPARγ2 gene expression in subcutaneous adipose tissue of male Wistar rats [PDF]
فصلنامه ابن سینا, 2021 Background and aims: PPARγ is one of the proteins that plays a very important role in regulating adipose tissue metabolism under physiological and metabolic conditions.
Ali Barzegari +2 more
doaj
Inhibition of Ubiquitin Ligase F-box and WD Repeat Domain-containing 7α (Fbw7α) Causes Hepatosteatosis through Krüppel-like Factor 5 (KLF5)/Peroxisome Proliferator-activated Receptor γ2 (PPARγ2) Pathway but Not SREBP-1c Protein in Mice [PDF]
, 2011 F-box and WD repeat domain-containing 7α (Fbw7α) is the substrate recognition component of a ubiquitin ligase that controls the degradation of factors involved in cellular growth, including c-Myc, cyclin E, and c-Jun.
Ema Masatsugu +31 more
core +1 more source