Cell Reports, 2016 The pathophysiologic continuum of non-alcoholic fatty liver disease begins with steatosis. Despite recent advances in our understanding of the gene regulatory program directing steatosis, how it is orchestrated at the chromatin level is unclear.
Dae-Hwan Kim +7 more
doaj +1 more source
Assessment of the Pro12Ala polymorphism in the PPAR-γ2 gene among type 2 diabetes patients in a Nigerian population [PDF]
, 2018 The association between the Pro12Ala polymorphism of the PPARγ2 gene, type 2 diabetes (T2D), and obesity in certain ethnic populations has been reported. However, this relationship has not yet been described among diabetes patients in Nigeria. This study
Chiezey, Venatus Osita +5 more
core +2 more sources
Transcriptional and epigenetic mechanisms underlying enhanced in vitro adipocyte differentiation by the brominated flame retardant BDE-47 [PDF]
, 2014 Recent studies suggest that exposure to endocrine-disrupting compounds (EDCs) may play a role in the development of obesity. EDCs such as the flame retardant 2,2′,4,4′-tetrabrominated diphenyl ether (BDE-47) have been shown to enhance adipocyte ...
Blumberg, B +6 more
core +3 more sources
Frontiers in Pharmacology, 2017 Objectives: Lotus leaf is a kind of traditional Chinese medicine. We aimed to explore the effects of lotus leaf aqueous extract (LLAE) on peroxisome proliferative activated receptor γ2 (PPARγ2) expression in preadipocytes and adipocytes and further ...
Kemin Yan +9 more
doaj +1 more source
Role of ox-PAPCs in the differentiation of mesenchymal stem cells (MSCs) and Runx2 and PPARγ2 expression in MSCs-like of osteoporotic patients. [PDF]
PLoS ONE, 2011 BACKGROUND: Mesenchymal stem cells (MSCs) can differentiate into osteoblasts and adipocytes and conditions causing bone loss may induce a switch from the osteoblast to adipocyte lineage.
Maria Teresa Valenti +7 more
doaj +1 more source
Frontiers in Endocrinology, 2022 The widely used lipid-lowering drug niacin was reported to increase blood glucose in diabetes. How does niacin regulate β Cell function in diabetic patients remains unclear.
Xiaojing Zhang +9 more
doaj +1 more source
Expression of the peroxisome proliferator activated receptor gamma gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes [PDF]
, 2009 Background Adipose tissues serve not only as a store for energy in the form of lipid, but also as endocrine tissues that regulates metabolic activities of the organism by secreting various kinds of hormones.
Katsunori Fujiki +3 more
core +2 more sources
Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]
, 2020 Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core +1 more source
Cardiovascular Diabetology, 2011 Background Metabolic Syndrome (MetS) results from the combined effect of environmental and genetic factors. We investigated the possible association of peroxisome proliferator-activated receptor-γ2 (PPARγ2) Pro12Ala and Angiotensin Converting Enzyme (ACE)
Passaro Angela +8 more
doaj +1 more source
Effects Of PPARγ2 Pro12Ala Variant On Adipocyte Phenotype Dependent Of DHA.
Diabetes, metabolic syndrome and obesity : targets and therapy, 2019 Peroxisome proliferator-activated receptor γ2 (PPARγ2) plays a critical role in the regulation of adipocyte differentiation and adipocytokine production. The Pro12Ala variant is the most common mutation in the PPARγ2 gene. Its effect appears to be sensitive to dietary factors, such as docosahexaenoic acid (DHA) level.
Wan,Renhui +4 more
openaire +4 more sources