Results 81 to 90 of about 430,860 (160)

Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression

Journal of Dairy Science
: The objective of this study was to evaluate the possible role of the peroxisome proliferator-activated receptors (PPAR: PPAR-α, PPAR-β/δ, and PPAR-γ) in diet and CLA-induced milk fat depression (MFD) in dairy cows.
A. Haile, D.E. Oliveira, Y.R. Boisclair, D.E. Bauman, K.J. Harvatine   +4 more
doaj   +1 more source

Suppression of KLF5 expression is mediated by PPAR-γ activation.

, 2015
Cells were pretreated with or without PPAR-γ antagonist GW9662 (3 mM) or BADGE (1 μM) for 30 min or PPAR-γ specific siRNA for 48 hrs prior before the addition of PPAR-γ activator rosiglitazone (Ros) (5μM), 15-d-PGJ2 (15D) (5μM) or pioglitazone (Pio) (50 ...
Zhe Meng (464162), Dengfeng Gao (464159), Zhongwei Liu (723226), Guanghua Hao (723225), Ning Ning (464160), Xin Dong (196020), Xiaolin Niu (487869), Guang Yang (154978)   +7 more
core   +1 more source

Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands

, 2016
Paecilocin A, a phthalide derivative isolated from the jellyfish-derived fungus Paecilomyces variotii, activates PPAR-γ (Peroxisome proliferator-activated receptor gamma) in rat liver Ac2F cells.
Jongki Hong, Min Yang, So Hyeon Eom, Sen Liu, Hae Young Chung, Jee H. Jung, Tae Noh, So Eom, Nam Kim, Nam Deuk Kim, Jee Jung, Hae Chung, Mingzhi Su, Tae Hwan Noh, Min Hye Yang   +14 more
core   +1 more source

PPAR-γ expression in rat astrocytes and microglia.

, 2013
(A and C) Gene expression was studied by RT-qPCR as described in Materials and Methods. No significant change in PPAR-γ mRNA levels was observed after 24 h of incubation with NDP-α-MSH in both cell types.
Carla Caruso (348124), Daniela Durand (348122), Lila Carniglia (348123), Mercedes Lasaga (336477)   +3 more
core   +1 more source

Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling pathway

Ecotoxicology and Environmental Safety
This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on TLR4/MyD88/MAPK pathway.
Mengjing Zhao, Min Zhang, Shoudong Ni
doaj   +1 more source

Citral inibe a inflamação aguda e nocicepção em camundongos: o papel dos receptores TLR4 e TLR2/DECTINA-1 [PDF]

, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Araranguá. Fisioterapia.Citral (3,7-dimethyl-2,6-octadienal), um monoterpeno de cadeia aberta e principal componente bioativo do capim limão, apresenta diferentes propriedades farmacológicas, tais ...
Gonçalves, Elaine Cristina Dalazen
core  

PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-β/δ and PPAR-γ

, 2017
The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of three members: PPAR-α, PPAR-β/δ and PPAR-γ.
Wen-Jun Shen, Stefanie Bittner, Salman Azhar, Lu Han, Fredric B Kraemer   +4 more
core   +1 more source

Peroxisome proliferator activated receptor-γ (PPAR-γ) ligands and angiogenesis

, 2003
The peroxisome proliferator activated receptor (PPAR)-γ ligands have been initially described as important regulators of adipogenic differentiation and glucose homeostasis.
Kouraklis, G., Margeli, A., Theocharis, S.   +2 more
core   +1 more source

Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR-γ expression and activation in macrophages

, 2018
The signal transducer and activator of transcription 6 (STAT6) transcription factor activates peroxisome proliferator-activated receptor gamma (PPAR-γ)-regulated gene expression in immune cells.
Young-So Yoon, Minsuk Kim, Myeong-Joo Kim, Ye-Ji Lee, Hee-Sun Kim, Ji Ha Choi, Jihee Lee Kang   +6 more
core   +1 more source

Unearthing novel PPAR-γ activators: In silico design of eucalyptol analogues for ulcerative colitis

Pakistan Journal of Pharmaceutical Sciences
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with rising prevalence, necessitating novel therapeutics. The peroxisome proliferator-activated receptor gamma (PPAR-γ) is a promising target for UC management.
Ozair Khurram Hashmi, Muhammad Hanzla, Calvin R. Wei, Muhammad Aashir Khan, Muhammad Wassam Bin Wasim, Muhammad Abdullah, Syed Hafiz Ahmed, Muhammad Osama   +7 more
doaj   +1 more source