Results 61 to 70 of about 430,860 (160)

15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

PPAR Research, 2019
15-Deoxy-∆-12,14-prostaglandin J2 (15d-PGJ2), a natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonist, has been explored in some detail over the last 20 years.
Jingjing Li, Chuanyong Guo, Jianye Wu
doaj   +1 more source

PPAR-γ expression is reduced in SSc.

, 2013
A. Expression of PPAR-γ and PAI-1 mRNA was determined by analyzing a previously described skin biopsy microarray dataset from a well-characterized cohort of scleroderma patients (n = 17) [25].
Jennifer L. Sargent (87901), Minghua Wu (129689), Jun Wei (208481), Michael L. Whitfield (87904), Asish K. Ghosh (360107), Carol Feghali-Bostwick (270228), Kazuhiro Komura (360109), Qi-Quan Huang (217194), Manu Jain (263718), John Varga (38678)   +9 more
core   +1 more source

PPAR-γ Activation Inhibits Angiogenesis by Blocking ELR+CXC Chemokine Production in Non-small Cell Lung Cancer

Neoplasia: An International Journal for Oncology Research, 2005
Activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) results in inhibition of tumor growth in various types of cancers, but the mechanism(s) by which PPAR-γ induces growth arrest has not been completely defined.
Venkateshwar G. Keshamouni, Douglas A. Arenberg, Raju C. Reddy, Michael J. Newstead, Shalini Anthwal, Theodore J. Standiford   +5 more
doaj   +1 more source

Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation

International Journal of Vascular Medicine, 2012
Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease.
Kousei Ohshima, Masaki Mogi, Masatsugu Horiuchi   +2 more
doaj   +1 more source

PPAR-γ protein expression.

, 2015
WIN induces PPAR-γ expression in astrocytes in primary culture treated with Aβ1–42. PPAR-γ and α-tubulin expressions were determined by Western-blot in astrocytes treated for 24 h with 10 μM Aβ40–1 (control peptide, C), 10 μM Aβ1–42 (Aβ), 10 μM WIN + 10 ...
Elena Obrador (559979), Maria D. Mauricio (721658), Sol Guerra-Ojeda (721655), Soraya L. Valles (559980), Martin Aldasoro (721656), Patricia Marchio (721660), Jose Mª Vila (721659), Diana Aguirre-Rueda (721654), Antonio Iradi (721657)   +8 more
core   +1 more source

FABP5 expression modulates PPAR-γ activity.

, 2013
A. FABP5 down regulation significantly decreases PPAR-γ activity in primary NHBE cell cultures. B. FABP5 up regulation significantly increases PPAR-γ activity in primary NHBE cell cultures. FABP5 shRNA − indicates cells that were knocked down for Firefly
Fabienne Gally (260470), Hong Wei Chu (193512), Russell P. Bowler (275738)   +2 more
core   +1 more source

Chemotherapeutic Drugs Induce PPAR-γ Expression and Show Sequence-Specific Synergy with PPAR-γ Ligands in Inhibition of Non–Small Cell Lung Cancer [PDF]

, 2008
Preclinical studies have shown that peroxisome proliferator–activated receptor γ (PPAR-γ) ligands can exert antitumor effects against non–small cell lung cancer (NSCLC) and a variety of other cancers.
Srinivasareddy Gangireddy, Reddy, Kaunteya, Jun Chen, Keshamouni, Venkateshwar G., Raju C. Reddy, Standiford, Theodore J., Anjaiah Srirangam, Chen, Jun, Gregory P. Kalemkerian, Venkateshwar G. Keshamouni, Reddy, Raju C., Gangireddy, Srinivasareddy, Srirangam, Anjaiah, Theodore J. Standiford, Kalemkerian, Gregory P., Kaunteya Reddy   +15 more
core   +1 more source

1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ in vivo and in vitro

Journal of Pharmaceutical Analysis
Vascular endothelial senescence is an important pathophysiological factor in the development and exacerbation of cardiovascular health problems linked to diabetes mellitus (DM). Accumulating evidence confirms that 1,8-cineole has multiple pharmacological
Lingyun Fu, Shidie Tai, Jiajia Liao, Youqi Du, Guangqiong Zhang, Die Guo, Xingmei Chen, Tian Zheng, Xiaoxia Hu, Wenbing Yao, Ling Tao, Xueting Wang, Yini Xu, Xiangchun Shen   +13 more
doaj   +1 more source

MHY 966 functioned as a PPAR α/γ dual agonist.

, 2013
(A) and (B), Docking simulation was performed to identify interaction between LBD and MHY 966. Docking modes of MHY 966 on the LBD of human PPAR α and γ.
So Ra Kim (458940), Daeui Park (468960), Hae Young Chung (310526), Hyung Ryong Moon (310525), Ji Young Park (310517), Ki Wung Chung (394795), Hye Jin Lee (67018), Hye Rim Kim (225882), Hyoung Oh Jeong (310518), Youngjoo Byun (468961), Dae Hyun Kim (267092), Min Hi Park (394794), Chan Hum Park (394796), Pusoon Chun (310524)   +13 more
core   +1 more source

Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma

Journal of Neuroinflammation, 2013
Background Palmitoylethanolamide (PEA) is an endogenous fatty acid amide displaying anti-inflammatory and analgesic actions. Moreover, several data have suggested that PEA reduced inflammation and tissue injury associated with spinal cord trauma and ...
Paterniti Irene, Impellizzeri Daniela, Crupi Rosalia, Morabito Rossana, Campolo Michela, Esposito Emanuela, Cuzzocrea Salvatore   +6 more
doaj   +1 more source