Results 51 to 60 of about 430,860 (160)

PPAR-γ in the Cardiovascular System

, 2008
Peroxisome proliferator-activated receptor-γ (PPAR-γ), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in ...
Christine Y. Ivashchenko, Richard M. Mortensen, Michael G. Usher, Sheng Zhong Duan   +3 more
core   +1 more source

Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

Molecules, 2020
The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for ...
Carmen Ciavarella, Ilenia Motta, Sabrina Valente, Gianandrea Pasquinelli   +3 more
doaj   +1 more source

Myeloid PPAR-γ deficiency leads to unresolved persistent fibrosis.

, 2019
(A) WT (Ppargfl/fl) or PPAR-γ cKO (PpargΔLyz2) mice were infected with influenza virus. H&E staining of lung sections from WT or PPAR-γ cKO mice at day 60 p.i.
Eva M. Carmona (7465466), Youngmin Son (7465463), Zheng Wang (25883), Su Huang (1722157), Bibo Zhu (1471021), Qigang Dai (714074), Li Jiang (120930), Chaofan Li (176970), Robert Vassallo (3108249), In Su Cheon (7465460), Min Xiang (1538941), Andrew H. Limper (7465469), Nick P. Goplen (7465457), Jie Sun (74648)   +13 more
core   +1 more source

Sildenafil Prevents Podocyte Injury via PPAR-γ-Mediated TRPC6 Inhibition [PDF]

, 2016
Transient receptor potential channel C6 (TRPC6) gain-of-function mutations and increased TRPC6 expression in podocytes induce glomerular injury and proteinuria.
van der Vlag, Johan, Dijkman, Henry B, Andrea M. Isidori, Berden, Jo H, Nijenhuis, Tom, Berden, J.H., ISIDORI, Andrea, Carole Henique, Henique, C., Johan van der Vlag, Joost G. Hoenderop, Tom Nijenhuis, Dijkman, H.B.P.M., Tharaux, P.L., Hoenderop, J.G.J., Isidori, A.M., Ramon Sonneveld, Vlag, J. van der, Pierre-Louis Tharaux, Sonneveld, Ramon, Henique, Carole, Henry B. Dijkman, Jo H. Berden, Hoenderop, Joost G, Sonneveld, R., Nijenhuis, T., Tharaux, Pierre Louis   +26 more
core   +2 more sources

PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty

Journal of Lipid Research, 2012
Peroxisome proliferator-activated receptor γ (PPAR-γ) is a key regulator of fatty acid metabolism, promoting its storage in adipose tissue and reducing circulating concentrations of free fatty acids. Activation of PPAR-γ has favorable effects on measures
Janice V. Huang, Clifford R. Greyson, Gregory G. Schwartz   +2 more
doaj   +1 more source

Anti-fibrogenic effect of PPAR-γ agonists in human intestinal myofibroblasts

BMC Gastroenterology, 2017
Background Intestinal fibrosis is a serious complication of inflammatory bowel disease, including Crohn’s disease and ulcerative colitis. There is no specific treatment for intestinal fibrosis.
Jun Bon Koo, Myeong-Ok Nam, Younshin Jung, Jongman Yoo, Duk Hwan Kim, Gwangil Kim, Sung Jae Shin, Kee Myung Lee, Ki Baik Hahm, Jong Woo Kim, Sung Pyo Hong, Kwang Jae Lee, Jun Hwan Yoo   +12 more
doaj   +1 more source

PPAR-γ activation increases insulin secretion through the up-regulation of the free fatty acid receptor GPR40 in pancreatic β-cells. [PDF]

PLoS ONE, 2013
BACKGROUND:It has been reported that peroxisome proliferator-activated receptor (PPAR)-γ and their synthetic ligands have direct effects on pancreatic β-cells.
Hyo-Sup Kim, You-Cheol Hwang, Seung-Hoi Koo, Kyong Soo Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Lee   +6 more
doaj   +1 more source

MHY908 functioned as a PPAR α/γ dual agonist.

, 2013
(A) The chemical structure of MHY908. (B) ChIP assay for PPARs binding to PPRE of the PPAR α or γ promoter. The extracted genomic DNA was subjected to immunoprecipitation using an antibody against PPAR α and PPAR γ or IgG as a negative control ...
Dae Hyun Kim (267092), Daeui Park (468960), Hae Young Chung (310526), Hyung Ryong Moon (310525), Min Hi Park (394794), Ji Young Park (310517), Hye Jin Lee (67018), Chan Hum Park (394796), Hyoung Oh Jeong (310518), Pusoon Chun (310524)   +9 more
core   +1 more source

PPAR-γ and aging: one link through klotho? [PDF]

, 2008
PPAR-γ, a transcription factor involved in adipogenesis, glucose homeostasis, bone turnover, and inflammation, has now been shown to increase klotho expression.
Zheng, Feng, Zhang, Ruihua
core   +1 more source

Three-in-One Agonists for PPAR-α, PPAR-γ, and PPAR-δ from Traditional Chinese Medicine

, 2012
[[abstract]]Nowadays, the occurrence of metabolic syndrome, which is characterized by obesity and clinical disorders, has been increasing rapidly over the world.
陳語謙;Chen, Calvin Yu-Chian
core