Results 31 to 40 of about 430,860 (160)

Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-γ as contributing to enhanced malaria surviva [PDF]

, 2010
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium ...
Winzeler, E.A., Wiltshire, T., Selina E R Bopp, Waters Andrew P., Andrew P. Waters, Luzader, A., Bopp, S.E.R., Waters, A.P., Steffy Brian M., Henson Kerstin, Winzeler Elizabeth A., Ramachandran, V., Suzuki Oscar, Lindstrom, M., Merle Lindstrom, Lindstrom Merle, Oscar Suzuki, Henson, K., Tim Wiltshire, Suzuki, O., Yingyao Zhou, Janse, C., Selina E. R. Bopp, Elizabeth A Winzeler, Spooner, M., Bopp Selina E. R., Zhou Yingyao, Brian M. Steffy, Kerstin Henson, Zhou, Y.Y., Chris Janse, Steffy, B.M., Janse Chris, Wiltshire Tim, Vandana Ramachandran, Muriel Spooner, Luzader Angelina, Angelina Luzader, Ramachandran Vandana, Spooner Muriel, Elizabeth A. Winzeler, Zhou, Y., Brian M Steffy, Andrew P Waters   +43 more
core   +2 more sources

PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model

Frontiers in Neuroscience, 2021
BackgroundPrevious studies have proved that peripheral nerve injury is involved in the pathogenesis of neuropathic pain (NP). The peripheral nerve injury primes spinal M1 microglia phenotype and produces pro-inflammatory cytokines, which are responsible ...
Xilei Li, Qulian Guo, Qulian Guo, Zhi Ye, Zhi Ye, E. Wang, E. Wang, Wangyuan Zou, Wangyuan Zou, Zhihua Sun, Zhihua Sun, Zhenghua He, Zhenghua He, Tao Zhong, Tao Zhong, Yingqi Weng, Yingqi Weng, Yundan Pan, Yundan Pan   +18 more
doaj   +1 more source

Resolving the Two “Bony” Faces of PPAR-γ

, 2006
Bone loss with aging results from attenuated and unbalanced bone turnover that has been associated with a decreased number of bone forming osteoblasts, an increased number of bone resorbing osteoclasts, and an increased number of adipocytes (fat cells ...
Larry J. Suva, Beata Lecka-Czernik
core   +1 more source

PPAR-γ Silencing Inhibits the Apoptosis of A549 Cells by Upregulating Bcl-2

Chinese Journal of Lung Cancer, 2013
Background and objective Drug resistance is the one of primary causes of death in patients with lung cancer, PPAR-γ could induce the apoptosis and reverse drug resistance.
Jingyu YANG
doaj   +1 more source

Peroxisome proliferator-activated receptor-gamma agonists suppress tissue factor overexpression in rat balloon injury model with paclitaxel infusion. [PDF]

PLoS ONE, 2011
The role and underlying mechanisms of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonist, on myocardial infarction are poorly understood.
Jun-Bean Park, Baek-Kyung Kim, Yoo-Wook Kwon, Dominik N Muller, Hyun-Chae Lee, Seock-Won Youn, Young-Eun Choi, Sae-Won Lee, Han-Mo Yang, Hyun-Jai Cho, Kyung Woo Park, Hyo-Soo Kim   +11 more
doaj   +1 more source

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis

Arthritis Research & Therapy, 2018
Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis.
Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga   +5 more
doaj   +1 more source

PPAR-γ antagonist-6hrs after reperfusion.

, 2018
Flow-cytometry shows how the effect on pro-inflammatory NO+ KC polarization was significantly blocked by the use of PPAR-γ antagonist (GW9662) (RGZ: 3.93±3.61%, RGZ+GW9662: 35.86±21.85%, Control: 31.12±21.42%, p = 0.009) (A).
Ivan Linares (5059373), Kaveh Farrokhi (5059358), Dagmar Kollmann (5059361), Peter Urbanellis (470094), Nazia Selzner (470098), Sujani Ganesh (5059370), Oyedele A. Adeyi (5059352), Markus Selzner (5059364), Johan Moritz Kaths (5059367), Paul Yip (255215), Juan Echeverri (5059376), Matyas Hamar (5059355)   +11 more
core   +1 more source

Kern-basierte Lernverfahren für das virtuelle Screening [PDF]

, 2010
We investigate the utility of modern kernel-based machine learning methods for ligand-based virtual screening. In particular, we introduce a new graph kernel based on iterative graph similarity and optimal assignments, apply kernel principle component ...
Rupp, Matthias
core  

PPAR-γ gene silencing decreases PPAR-γ protein levels and activity in ovine pulmonary arterial endothelial cells.

, 2013
Protein extracts (20 µg) prepared from PAEC transfected with a PPAR-γ siRNA or a scrambled control for 48 h, were analyzed by Western blot analysis and a significant decrease in PPAR-γ protein levels was observed (A).
Ruslan Rafikov (308925), Sanjeev A. Datar (308931), Gary Raff (308933), Stephen M. Black (194811), Shruti Sharma (308114), Sanjiv Kumar (308927), Yali Hou (252579), Jeffrey R. Fineman (308935), Xutong Sun (308115), Peter E. Oishi (308929)   +9 more
core   +1 more source

High Fat Diet Upregulates Fatty Acid Oxidation and Ketogenesis via Intervention of PPAR-γ

Cellular Physiology and Biochemistry, 2018
Background/Aims: Systemic hyperlipidemia and intracellular lipid accumulation induced by chronic high fat diet (HFD) leads to enhanced fatty acid oxidation (FAO) and ketogenesis.
Kunal Sikder, Sanket Kumar Shukla, Neel Patel, Harpreet Singh, Khadija Rafiq   +4 more
doaj   +1 more source