Results 21 to 30 of about 430,860 (160)

Skin-targeted inhibition of PPAR β/δ by selective antagonists to treat PPAR β/δ-mediated psoriasis-like skin disease in vivo [PDF]

, 2012
We have previously shown that peroxisome proliferator activating receptor ß/d (PPAR ß/d is overexpressed in psoriasis. PPAR ß/d is not present in adult epidermis of mice.
Kevin D. Read (165019), Palmer Colin, Kally Booth, Katrin Hack, Booth Kally, Colin Palmer (165015), Suzanne Norval, Read, Kevin D, Hack Katrin, John Foerster (165047), Robert Kime, Kevin D Read, John Foerster, Kally Booth (165039), Louise Reilly, Suzanne Norval (165024), Read Kevin D., Palmer, Colin; id_orcid, Norval, Suzanne, Reilly, Louise, Louise Reilly (165006), Reilly Louise, Read, Kevin, Palmer, Colin, Hack, Katrin, Robert Kime (165030), Colin Palmer, Kime Robert, Foerster John, Foerster, John, Katrin Hack (165002), Kime, Robert, Norval Suzanne, Booth, Kally   +33 more
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Probiotic bacteria produce conjugated linoleic acid locally in the gut that targets macrophage PPAR γ to suppress colitis. [PDF]

, 2012
Inflammatory bowel disease (IBD) therapies are modestly successful and associated with significant side effects. Thus, the investigation of novel approaches to prevent colitis is important.
Vogel, Hans, Christian Jobin (74703), Adria Carbo, Mireia Pedragosa, Jobin, Christian, Christian Jobin, Monica Viladomiu (120075), Carbo, Adria, Mireia Pedragosa (120080), Janelle C Arthur, Martin Storr (124415), Hans Vogel (182237), Benjamin A. Corl (182236), Hans Vogel, Viladomiu, Monica, Adria Carbo (120066), Arthur, Janelle C., Shaykhutdinov, Rustem, Pedragosa, Mireia, Storr, Martin, Raquel Hontecillas (120113), Bassaganya-Riera, Josep, De Simone, Claudio, Janelle C. Arthur (143340), Claudio De Simone (171437), Monica Viladomiu, Rustem Shaykhutdinov (182227), Rustem Shaykhutdinov, Martin Storr, Claudio De Simone, Josep Bassaganya-Riera (120051), Hontecillas, Raquel, Benjamin A Corl, Josep Bassaganya-Riera, Corl, Benjamin A., Raquel Hontecillas   +35 more
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Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism [PDF]

, 2008
Plasma lipoproteins are responsible for carrying triglycerides and cholesterol in the blood and ensuring their delivery to target organs. Regulation of lipoprotein metabolism takes place at numerous levels including via changes in gene transcription.
Kersten, A.H., Sander Kersten
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Synthesis, molecular docking, and in vivo antidiabetic evaluation of new benzylidene-2,4-thiazolidinediones as partial PPAR-γ agonists

Scientific Reports, 2023
Peroxisome proliferator-activated receptor-γ (PPAR-γ) partial agonists or antagonists, also termed as selective PPAR-γ modulators, are more beneficial than full agonists because they can avoid the adverse effects associated with PPAR-γ full agonists ...
Asim Najmi, Md Shamsher Alam, Neelaveni Thangavel, Manal M. E. Taha, Abdulkarim M. Meraya, Mohammed Albratty, Hassan A. Alhazmi, Waquar Ahsan, Anzarul Haque, Faizul Azam   +9 more
doaj   +1 more source

Peroxisome-Proliferator-Activated Receptor (PPAR)-γ Activation Stimulates Keratinocyte Differentiation [PDF]

, 2004
Previous studies demonstrated that peroxisome-proliferator-activated receptor (PPAR)-α or PPAR-δ activation stimulates keratinocyte differentiation, is anti-inflammatory, and improves barrier homeostasis.
Li, Mei, Fowler, A.J., Metzger, Daniel, Wahli, Walter, Elias, Peter M., Feingold, Kenneth R., Chambon, P.H., Fowler, Ashley, Chambon, Pierre, Michalik, L., Elias, Peter, Brown, Barbara E., Michalik, Liliane, Desvergne, Beatrice, Fowler, Ashley J., Moser, Arthur H., Mao-Qiang, Man, Desvergne, B., Lau, Peggy, Brown, B.E., Li, M., Metzger, D., Chang, Sandra, Wahli, W., Elias, P.M., Feingold, Kenneth, Feingold, K.R., Schmuth, Matthias, Chang, S., Chambon, Pierre H., Moser, Arthur, Lau, P., Moser, A.H., Mao-Qiang, M., Schmuth, M., Brown, Barbara   +35 more
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PPAR-γ agonist protects podocytes from injury [PDF]

, 2007
Podocyte injury and loss contribute to progressive glomerulosclerosis. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor, which we have found to be increased in podocytes in a variety of kidney diseases.
Guan, Y., Kanjanabuch, T., Pozzi, A., Chen, J., Fogo, A.-B., Mundel, P., Ma, L.-J.   +6 more
core   +1 more source

Klotho is a target gene of PPAR-γ [PDF]

, 2008
Klotho is an anti-aging gene whose expression is regulated by many stimuli. Here we examined the transcriptional regulation of the klotho gene by peroxisome proliferator-activated receptor-γ (PPAR-γ). The PPAR-γ agonists thiazolidinediones increased both
Wu, Jing, Zhao, Beilei, Li, Yuanyuan, Zhang, Hong, Chien, Shu, Fan, Yanbo, Guan, Youfei, Wang, Nanping   +7 more
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Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases [PDF]

, 2012
A direct correlation between adequate nutrition and health is a universally accepted truth. The Western lifestyle, with a high intake of simple sugars, saturated fat, and physical inactivity, promotes pathologic conditions.
Marquez-Aguirre, AL, A. L. Márquez-Aguirre, A. E. Rojas-Mayorquín, S. Quintero-Fabián, D. Ortuño Sahagún, Marquez-Aguirre, A.L., Lopez-Roa, R.I., Rojas-Mayorquin, AE, Quintero-Fabian, S., Rojas-Mayorquin, A.E., Sahagun, DO, Quintero-Fabian, S, R. I. López-Roa, Lopez-Roa, RI, Ortuno Sahagun, D.   +14 more
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Peroxisome Proliferator-Activated Receptor γ Negatively Regulates Allergic Rhinitis in Mice

Allergology International, 2009
Background: Peroxisome proliferator-activated receptor γ (PPAR-γ) has been shown to play an important role in the control of inflammatory responses acting on macrophages, mast cells, T cells, and eosinophils.
Naoko Fukui, Kohei Honda, Eiko Ito, Kazuo Ishikawa   +3 more
doaj   +1 more source

PPAR-γ protein expression.

, 2016
Astrocytes (panel A) or neurons (panel B) were incubated without Rn (control, C) or with Rn (10−7, 10−6, 10−5 M) for 24 h and collected to determine PPAR-γ protein expression by Western blot. A representative immunoblot is shown in the top panel.
Elena Obrador (559979), Mª Dolores Mauricio (3181626), Sol Guerra-Ojeda (721655), Soraya L. Valles (559980), Martin Aldasoro (721656), Patricia Marchio (721660), Constanza Aldasoro (3181629), Jose Mª Vila (721659), Diana Aguirre-Rueda (721654), Antonio Iradi (721657), Adrian Jorda (3181632)   +10 more
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