Results 41 to 50 of about 430,860 (160)
BiomedicinesAim: Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) plays important anti-inflammatory roles, including in periodontitis. This systematic review with a meta-analysis compiles evidence on the transcriptional and translational levels of PPAR-γ in
Marco Antonio Rimachi Hidalgo +4 more
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Mediators of Inflammation, 2019 Persistent inflammation disrupts functional recovery after spinal cord injury (SCI). Peroxisome proliferator-activated receptor gamma (PPAR-γ) activation promotes functional recovery in SCI rats by inhibiting inflammatory cascades and increasing neuronal
Qing-Qi Meng +6 more
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Frontiers in Pharmacology, 2022 Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections,
Vinesh Sharma +3 more
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A synthetic PPAR-γ agonist triterpenoid ameliorates experimental fibrosis: PPAR-γ-independent suppression of fibrotic responses [PDF]
, 2016 Background: Persistent fibroblast activation initiated by transforming growth factor β (TGF-β) is a fundamental event in the pathogenesis of systemic sclerosis, and its pharmacological inhibition represents a potential therapeutic strategy.
Doniparthi, Sruthi +10 more
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Synthesis of PPAR-γ Activators Inspired by the Marine Natural Product, Paecilocin A
Marine Drugs, 2014 A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads.
Bin Xiao +7 more
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Regenerative Therapy, 2020 Introduction: Peroxisome proliferator–activated receptor (PPAR) subfamily play an important role in chondrogenesis. Previous study has reported that mixture of GW0742 (PPAR-δ agonist), hyaluronic acid (HA) and mesenchymal stem cells (MSCs) enhance ...
Dong Hyun Kim +5 more
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PLoS ONE, 2013 Peroxisome proliferator-activated receptor-γ (PPAR-γ) has recently emerged as potential therapeutic agents for cerebral ischemia-reperfusion (I/R) injury because of anti-neuronal apoptotic actions.
Feng Xu +4 more
doaj +1 more source
Overexpression of the PPAR‑γ protein in primary Ta/T1 non‑muscle‑invasive urothelial carcinoma [PDF]
, 2022 香川県立保健医療大学博士（臨床検査学）application/pdfPeroxisome proliferator‑activated receptor‑γ(PPAR‑γ) is a well‑known nuclear receptor that is activated in the nucleus to regulate several transcription factors.
Yamamoto, Tamami +7 more
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QSAR Analysis of 5-Substituted-2-Benzoyl-aminobenzoic acids as PPAR Modulator
E-Journal of Chemistry, 2004 A quantitative structure activity relationship (QSAR) study on a series of analogs of 5-aryl thiazolidine-2, 4-diones with activity on PPAR-α and PPAR-γ was made using combination of various thermodynamic, electronic and spatial descriptors.
R. Hemalatha +3 more
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Frontiers in Physiology, 2018 Renin angiotensin system (RAS) blockade reduces the progression of chronic kidney disease (CKD) independently of its antihypertensive effect. Ang II-induced fibrosis can be mediated by molecules such as klotho, peroxisome proliferator-activate receptor γ
Edgar Maquigussa +7 more
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