Results 11 to 20 of about 430,860 (160)

PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia [PDF]

PPAR Research, 2017
Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti ...
Sarawin Harnchoowong, Poonkiat Suchonwanit   +1 more
doaj   +2 more sources

PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells [PDF]

PPAR Research, 2010
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) is a member of the nuclear receptor (NR) superfamily of ligand-activated transcriptional factors. Among other functions, PPAR-γ acts as a key regulator of the adipogenesis.
Ichiro Takada, Alexander P. Kouzmenko, Shigeaki Kato   +2 more
doaj   +2 more sources

PPAR-γ Regulates Trophoblast Differentiation in the BeWo Cell Model

PPAR Research, 2014
Common pregnancy complications, such as severe preeclampsia and intrauterine growth restriction, disrupt pregnancy progression and impair maternal and fetal wellbeing.
Khrystyna Levytska, Sascha Drewlo, Dora Baczyk, John Kingdom   +3 more
doaj   +3 more sources

Protective Actions of PPAR-γ Activation in Renal Endothelium [PDF]

PPAR Research, 2008
Renal endothelial damage is pivotal in the initiation and progression of renal disease. Damaged renal endothelium may be regenerated through proliferation of local endothelium and circulation-derived endothelial progenitor cells.
Peter E. Westerweel, Marianne C. Verhaar
doaj   +2 more sources

PPAR-γ Ligand Inhibits Nasopharyngeal Carcinoma Cell Proliferation and Metastasis by Regulating E2F2

PPAR Research, 2019
Purpose. Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a nuclear hormone receptor with a key role in lipid metabolism. Previous studies have identified various roles of PPAR-γ in cell cycle progression, cellular proliferation, and tumor ...
Ping-Li Yang, Jia-Shun Wang, Xiao-Mei Cheng, Jing-Cai Chen, Hui Zhu, Xiao-Lan Li, Li Cao, Wei Tang   +7 more
doaj   +2 more sources

PPAR-γ Agonist Alleviates Liver and Spleen Pathology via Inducing Treg Cells during Schistosoma japonicum Infection

Journal of Immunology Research, 2018
Background. Peroxisome proliferator-activated receptor- (PPAR-) γ plays critical roles in human metabolic disorders and has recently been implicated as a regulator of cellular proliferation and inflammatory responses.
Yuxiao Zhu, Yangyue Ni, Ran Liu, Min Hou, Bingya Yang, Jingwei Song, Hongzhi Sun, Zhipeng Xu, Minjun Ji   +8 more
doaj   +2 more sources

PPAR-γ regulates the effector function of human TH9 cells by promoting glycolysis [PDF]

, 2022
T helper 9 cells (TH9) are key drivers of allergic tissue inflammation. They are characterized by the expression of type 2 cytokines, such as IL-9 and IL-13, and the peroxisome proliferator-activated receptor gamma (PPAR-γ) transcription factor. However,
Friedli, Olivier, Nadja Begré, Max Philip Gabutti, Irene Keller, Luther, Fabian, Cristina Lamos, Steck, Oliver, Schlapbach, Christoph, Cecilia Bazzini, Dagmar Simon, Freigang, Stefan, Christoph Schlapbach, Oliver Steck, Begré, Nadja, Stefan Freigang, Nicole L. Bertschi, Jean-Marc Nuoffer, Lamos, Cristina, Felser, Andrea, Keller, Irene, Benzaquen, Michael, Olivier Friedli, Fabian Luther, Gabutti, Max Philip, Bazzini, Cecilia, Bertschi, Nicole L, Markus Laimer, Andrea Felser, Michael Benzaquen, Leonhard von Meyenn, Nuoffer, Jean-Marc, Laimer, Markus, Simon, Dagmar, von Meyenn, Leonhard   +33 more
core   +2 more sources

PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis. [PDF]

, 2023
T helper 9 (TH9) cells promote allergic tissue inflammation and express the type 2 cytokines, IL-9 and IL-13, as well as the transcription factor, PPAR-γ. However, the functional role of PPAR-γ in human TH9 cells remains unknown.
Friedli, Olivier, Nadja Begré, Max Philip Gabutti, Schärli, Stefanie, Irene Keller, Luther, Fabian, Cristina Lamos, Steck, Oliver, Schlapbach, Christoph, Cecilia Bazzini, Dagmar Simon, Freigang, Stefan, Angela Vallone, Susanne Radonjic-Hoesli, Christoph Schlapbach, Vallone, Angela, Oliver Steck, Begré, Nadja, Stefan Freigang, Nicole L. Bertschi, Jean-Marc Nuoffer, Lamos, Cristina, Felser, Andrea, Keller, Irene, Benzaquen, Michael, Olivier Friedli, Fabian Luther, Gabutti, Max Philip, Bazzini, Cecilia, Bertschi, Nicole L, Markus Laimer, Andrea Felser, Michael Benzaquen, Stefanie Schärli, Leonhard von Meyenn, Nuoffer, Jean-Marc, Laimer, Markus, Simon, Dagmar, Radonjic-Hoesli, Susanne, von Meyenn, Leonhard   +39 more
core   +2 more sources

Peroxisome Proliferator-Activated Receptor-γ Modulates the Response of Macrophages to Lipopolysaccharide and Glucocorticoids

Frontiers in Immunology, 2018
Although glucocorticoids (GC) represent the most frequently used immunosuppressive drugs, their effects are still not well understood. In our previous studies, we have shown that treatment of monocytes with GC does not cause a global suppression of ...
Michael Heming, Michael Heming, Sandra Gran, Saskia-L. Jauch, Lena Fischer-Riepe, Antonella Russo, Luisa Klotz, Sven Hermann, Michael Schäfers, Johannes Roth, Katarzyna Barczyk-Kahlert   +10 more
doaj   +1 more source

Pengaruh Pemberian Mesenchymal Stem Cells Wharton’s Jelly terhadap Ekspresi Gen PPAR-γ pada Tikus Alzheimer

Jurnal Kesehatan Andalas, 2023
The increased production of beta-amyloid marks Alzheimer's disease. PPAR-γ shows involvement in Alzheimer's disease. PPAR-γ Gene is suspected to reduce beta-amyloid plaques and reduce inflammation and oxidative stress in Alzheimer's disease.
Nabila Priscilla Putri, Hirowati Ali, Tofrizal Tofrizal, Eryati Darwin, Restu Susanti, Hasmiwati Hasmiwati   +5 more
doaj   +1 more source