Results 221 to 230 of about 23,167 (255)

PPARG Gene Polymorphism and Locomotor Activity in Humans

Bulletin of Experimental Biology and Medicine, 2008
The distribution of PPARG gene allele frequencies (Pro/Ala polymorphism) was studied in sportsmen specialized in speed and force athletics. A relationship between genotypes and human muscle transverse section area was evaluated. The PPARG Ala allele was significantly more incident in athletes than in controls, the incidence increasing with higher ...
I I, Ahmetov, I A, Mozhayskaya, E V, Lyubaeva, O L, Vinogradova, V A, Rogozkin   +4 more
openaire   +2 more sources

Muscle-specific Pparg deletion causes insulin resistance

Nature Medicine, 2003
Thiazolidinediones (TZDs) are insulin-sensitizing drugs and are potent agonists of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Although muscle is the major organ responsible for insulin-stimulated glucose disposal, PPAR-gamma is more highly expressed in adipose tissue than in muscle. To address this issue, we used the Cre-
Hevener, A L, He, W, Barak, Y, Le, J, Bandyopadhyay, G, Olson, P, Wilkes, J, Evans, R M, Olefsky, J   +8 more
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No association between the PPARG gene and schizophrenia in a British population

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2009
It has consistently been reported that patients with schizophrenia have an increased risk of type-2 diabetes. To investigate a genetic link between these two diseases, the combined effects of the PLA2G4A, PTGS2 and PPARG genes were tested among 221 British nuclear families consisting of fathers, mothers and affected offspring with schizophrenia.
Aditi, Mathur, Matthew H, Law, Tayebeh, Hamzehloei, Ian L, Megson, Duncan J, Shaw, Jun, Wei   +5 more
openaire   +2 more sources

EFFECT OF PPARG INHIBITION ON HUMAN BMSC CELL FATE

Orthopaedic Proceedings
The effects of dexamethasone (dex), during in vitro human osteogenesis, are contrasting. Indeed, dex downregulates SOX9 during osteogenic differentiation of human bone marrow mesenchymal stromal cells (HBMSCs). However, dex also promotes PPARG expression, resulting in the formation of adipocyte-like cells within the osteogenic monolayers.
Maria Rosa Iaquinta, Carmen Lanzillotti, Mauro Tognon, Fernanda Martini, Martin J Stoddart, Elena Della Bella   +5 more
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Novel PPARG mutation in multiple family members with chylomicronemia

Journal of Clinical Lipidology, 2021
Robert Eckelr, , Robert Hegele
exaly  

PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss

Bone, 2021
Beata Lecka-Czernik, Patrick Griffin, Sudipta Baroi   +2 more
exaly  

Correlation between PPARG Pro12Ala Polymorphism and Therapeutic Responses to Thiazolidinediones in Patients with Type 2 Diabetes: A Meta-Analysis

Pharmaceutics, 2023
Jeong Yee, Hye Sun Gwak, Da Hoon Lee
exaly  

Inhibition of ALKBH5‐mediated m6A modification of PPARG mRNA alleviates H/R‐induced oxidative stress and apoptosis in placenta trophoblast

Environmental Toxicology, 2022
Yali Yang
exaly  

PPARG: A Novel Target for Yellow Tea in Kidney Stone Prevention

International Journal of Molecular Sciences, 2023
Mingjie Su, Hui Li, Siyao Sang
exaly  

[PPARG gene polymorphism and disease susceptibility].

Nihon rinsho. Japanese journal of clinical medicine, 2010
PPARgamma plays a key role in the regulation of adipocyte differentiation and energy balance. The polymorphism in human PPARG gene resulting in the substitution of Pro12 to Ala in the PPARgamma2 isoform has been established as conferring anti-diabetic and anti-obesity effects, especially in the conditions such as westernized lifestyle with high levels ...
openaire   +1 more source